<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019b4bf3-eebb-7d84-a877-3727eb3e1c2a,g:c37c839a-14e9-481b-a25d-de27fe0ebd44-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="simple" xlink:href="ttwo-20251231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019b4bf3-f02d-7ec3-9f43-e2b1a51977ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_StatementTable_019b4bf3-f02d-7ec3-9f43-e2b1a51977ba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019b4bf3-f02d-7ec3-9f43-e2b1a51977ba" xlink:to="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8" xlink:to="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7ede-956b-66ee00e0a669" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-754d-ac06-b4ba7bb8c6e8" xlink:to="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7ede-956b-66ee00e0a669" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_GameMember_019b4bf3-f02d-7e7e-b40e-3efbc45cc7f9" xlink:href="ttwo-20251231.xsd#ttwo_GameMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7ede-956b-66ee00e0a669" xlink:to="loc_ttwo_GameMember_019b4bf3-f02d-7e7e-b40e-3efbc45cc7f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingMember_019b4bf3-f02d-7f2f-9507-d3c637af26d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdvertisingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7ede-956b-66ee00e0a669" xlink:to="loc_us-gaap_AdvertisingMember_019b4bf3-f02d-7f2f-9507-d3c637af26d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f02d-71d8-8139-7ab249070803" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f02d-71d8-8139-7ab249070803" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019b4bf3-f02d-7da5-b142-a19e88f2f2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_CostOfRevenue_019b4bf3-f02d-7da5-b142-a19e88f2f2a8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019b4bf3-f02d-7630-b3bf-d3d8f8b6a8ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_GrossProfit_019b4bf3-f02d-7630-b3bf-d3d8f8b6a8ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_019b4bf3-f02d-7a5c-9ced-0e10a62f9990" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_SellingAndMarketingExpense_019b4bf3-f02d-7a5c-9ced-0e10a62f9990" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_019b4bf3-f02d-7cba-89a7-81542fdb5cb0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_019b4bf3-f02d-7cba-89a7-81542fdb5cb0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019b4bf3-f02d-747f-bffc-d5dec793ec23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019b4bf3-f02d-747f-bffc-d5dec793ec23" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019b4bf3-f02d-79cd-bdc7-b25643f9a6ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019b4bf3-f02d-79cd-bdc7-b25643f9a6ac" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019b4bf3-f02d-7c0f-9a34-41dfcb9fc92c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_RestructuringCharges_019b4bf3-f02d-7c0f-9a34-41dfcb9fc92c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019b4bf3-f02d-7872-9994-d1d2b05ad765" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_OperatingExpenses_019b4bf3-f02d-7872-9994-d1d2b05ad765" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019b4bf3-f02d-735b-9a26-05ed1935dbb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_OperatingIncomeLoss_019b4bf3-f02d-735b-9a26-05ed1935dbb9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019b4bf3-f02d-7715-9dfa-31c3ac7d6301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019b4bf3-f02d-7715-9dfa-31c3ac7d6301" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b4bf3-f02d-72c3-8d82-b6a1b3826046" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b4bf3-f02d-72c3-8d82-b6a1b3826046" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019b4bf3-f02d-7b51-8dfb-f5dba92b189d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019b4bf3-f02d-7b51-8dfb-f5dba92b189d" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019b4bf3-f02d-7788-958d-12df858029a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_NetIncomeLoss_019b4bf3-f02d-7788-958d-12df858029a8" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_019b4bf3-f02d-70f9-a335-c20a6e924305" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-7fc0-b465-421599bfd567" xlink:to="loc_us-gaap_EarningsPerShareAbstract_019b4bf3-f02d-70f9-a335-c20a6e924305" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019b4bf3-f02d-7bc6-88a7-e15886ac468a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019b4bf3-f02d-70f9-a335-c20a6e924305" xlink:to="loc_us-gaap_EarningsPerShareBasic_019b4bf3-f02d-7bc6-88a7-e15886ac468a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019b4bf3-f02d-75f5-aec4-9986069abbec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019b4bf3-f02d-70f9-a335-c20a6e924305" xlink:to="loc_us-gaap_EarningsPerShareDiluted_019b4bf3-f02d-75f5-aec4-9986069abbec" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited" xlink:type="simple" xlink:href="ttwo-20251231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFEQUITYUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019b4bf3-f02d-7ccf-9d95-1852850a49b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StatementTable_019b4bf3-f02d-7ccf-9d95-1852850a49b0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f02d-7383-bec0-525a5373a8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019b4bf3-f02d-7ccf-9d95-1852850a49b0" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f02d-7383-bec0-525a5373a8a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7383-bec0-525a5373a8a3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f02d-7383-bec0-525a5373a8a3" xlink:to="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7383-bec0-525a5373a8a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f02d-7383-bec0-525a5373a8a3" xlink:to="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019b4bf3-f02d-7e42-9bde-24737ea4d07f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:to="loc_us-gaap_CommonStockMember_019b4bf3-f02d-7e42-9bde-24737ea4d07f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019b4bf3-f02d-713f-b43d-a0bca5fa6755" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019b4bf3-f02d-713f-b43d-a0bca5fa6755" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_019b4bf3-f02d-7e0d-80d8-8af2de7b1501" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:to="loc_us-gaap_TreasuryStockCommonMember_019b4bf3-f02d-7e0d-80d8-8af2de7b1501" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019b4bf3-f02d-716e-ac0f-6c771fe39049" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:to="loc_us-gaap_RetainedEarningsMember_019b4bf3-f02d-716e-ac0f-6c771fe39049" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019b4bf3-f02d-7e44-851e-6c0a526a5a92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f02d-7f00-89f1-0a49d93b8c4f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019b4bf3-f02d-7e44-851e-6c0a526a5a92" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f02d-7ba9-a8ca-f02956a53d90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019b4bf3-f02d-7ccf-9d95-1852850a49b0" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f02d-7ba9-a8ca-f02956a53d90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7ba9-a8ca-f02956a53d90_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f02d-7ba9-a8ca-f02956a53d90" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7ba9-a8ca-f02956a53d90_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7853-bb29-51102e5de1db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f02d-7ba9-a8ca-f02956a53d90" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7853-bb29-51102e5de1db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZyngaIncMember_019b4bf3-f02d-7c20-b478-b47bc3bb0cd9" xlink:href="ttwo-20251231.xsd#ttwo_ZyngaIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7853-bb29-51102e5de1db" xlink:to="loc_ttwo_ZyngaIncMember_019b4bf3-f02d-7c20-b478-b47bc3bb0cd9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_GearboxMember_019b4bf3-f02d-73ac-99c5-ca976b78e1a5" xlink:href="ttwo-20251231.xsd#ttwo_GearboxMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f02d-7853-bb29-51102e5de1db" xlink:to="loc_ttwo_GearboxMember_019b4bf3-f02d-73ac-99c5-ca976b78e1a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019b4bf3-f02d-75b8-8527-d08a8109908d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019b4bf3-f02d-75b8-8527-d08a8109908d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019b9da4-a5c8-7dd3-8721-882909a84d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockholdersEquity_019b9da4-a5c8-7dd3-8721-882909a84d9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019b4bf3-f02d-7833-bd63-08fd3d3d9ee9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_TreasuryStockCommonShares_019b4bf3-f02d-7833-bd63-08fd3d3d9ee9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019b4bf3-f02d-7fbb-81a5-b2d297e9bf09" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_NetIncomeLoss_019b4bf3-f02d-7fbb-81a5-b2d297e9bf09" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019b4bf3-f02d-767b-91f6-7a65501c5547" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019b4bf3-f02d-767b-91f6-7a65501c5547" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019b4bf3-f02d-76a7-9b35-92fcf5e647eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019b4bf3-f02d-76a7-9b35-92fcf5e647eb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_019b4bf3-f02d-750f-854b-a4134fcb1e51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_019b4bf3-f02d-750f-854b-a4134fcb1e51" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019b4bf3-f02d-71dd-8cd5-791ec10a6223" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019b4bf3-f02d-71dd-8cd5-791ec10a6223" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019b9da5-7397-7ea0-bb95-fd3187f4f594" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019b9da5-7397-7ea0-bb95-fd3187f4f594" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_019b4bf3-f02d-786f-aa10-d56a79900ef4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_019b4bf3-f02d-786f-aa10-d56a79900ef4" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_019b4bf3-f02d-7ea2-b73f-f6381997c396" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_019b4bf3-f02d-7ea2-b73f-f6381997c396" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_019b4bf3-f02d-7917-8ec1-2d766440249a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_019b4bf3-f02d-7917-8ec1-2d766440249a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares_019b4bf3-f02d-7ff1-9d65-f901060a8736" xlink:href="ttwo-20251231.xsd#ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares_019b4bf3-f02d-7ff1-9d65-f901060a8736" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlan_019b4bf3-f02d-7254-8806-5a639e9703a5" xlink:href="ttwo-20251231.xsd#ttwo_SettlementRelatedToEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_ttwo_SettlementRelatedToEmployeeStockPurchasePlan_019b4bf3-f02d-7254-8806-5a639e9703a5" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019be8e3-adee-7999-890e-37925ec67ca4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019be8e3-adee-7999-890e-37925ec67ca4" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019b4bf3-f02d-79d2-bc20-fa979bbaa2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019b4bf3-f02d-79d2-bc20-fa979bbaa2b5" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_019b4bf3-f02d-7693-91b0-ba4ac4349581" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019b4bf3-f02d-72d3-89ae-ba1f953eeadb" xlink:to="loc_us-gaap_StockholdersEquityOther_019b4bf3-f02d-7693-91b0-ba4ac4349581" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019b4bf3-f02d-772d-b856-0bd5bdcbbcce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ba7e1-9b01-76bc-9972-52ccbaecc361" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019b4bf3-f02d-7f33-b6d1-b2cb387b07fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonShares"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019b4bf3-f02d-7b16-b737-650b1cf9ed63" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019b4bf3-f02d-72ba-8404-b8a0ebd9593d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019b4bf3-f02d-7b16-b737-650b1cf9ed63" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019b4bf3-f02d-72ba-8404-b8a0ebd9593d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019b4bf3-f02d-78f3-8c17-e642fec821f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019b4bf3-f02d-72ba-8404-b8a0ebd9593d" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019b4bf3-f02d-78f3-8c17-e642fec821f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-78f3-8c17-e642fec821f8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019b4bf3-f02d-78f3-8c17-e642fec821f8" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-78f3-8c17-e642fec821f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-7cab-9cdf-3254ac3a7412" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_019b4bf3-f02d-78f3-8c17-e642fec821f8" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-7cab-9cdf-3254ac3a7412" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember_019b4bf3-f02d-7119-bf28-9acb2eacc817" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransferredOverTimeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-7cab-9cdf-3254ac3a7412" xlink:to="loc_us-gaap_TransferredOverTimeMember_019b4bf3-f02d-7119-bf28-9acb2eacc817" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredAtPointInTimeMember_019b4bf3-f02d-7beb-97ff-91bec93d6f09" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransferredAtPointInTimeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_019b4bf3-f02d-7cab-9cdf-3254ac3a7412" xlink:to="loc_us-gaap_TransferredAtPointInTimeMember_019b4bf3-f02d-7beb-97ff-91bec93d6f09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-7b51-aee7-9b6ebd62732d" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019b4bf3-f02d-72ba-8404-b8a0ebd9593d" xlink:to="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-7b51-aee7-9b6ebd62732d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7b51-aee7-9b6ebd62732d_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-7b51-aee7-9b6ebd62732d" xlink:to="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-7b51-aee7-9b6ebd62732d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019b4bf3-f02d-7b51-aee7-9b6ebd62732d" xlink:to="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RecurrentCustomerSpendingMember_019b4bf3-f02d-78e6-95e7-6648d5489240" xlink:href="ttwo-20251231.xsd#ttwo_RecurrentCustomerSpendingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_RecurrentCustomerSpendingMember_019b4bf3-f02d-78e6-95e7-6648d5489240" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_FullGameAndOtherMember_019b4bf3-f02d-7a55-a147-ccc4f1562f0c" xlink:href="ttwo-20251231.xsd#ttwo_FullGameAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_FullGameAndOtherMember_019b4bf3-f02d-7a55-a147-ccc4f1562f0c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MobileMember_019b4bf3-f02d-7dd5-b8e3-a9df3cfb2a45" xlink:href="ttwo-20251231.xsd#ttwo_MobileMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_MobileMember_019b4bf3-f02d-7dd5-b8e3-a9df3cfb2a45" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConsoleMember_019b4bf3-f02d-71b0-972c-d7306ea56022" xlink:href="ttwo-20251231.xsd#ttwo_ConsoleMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_ConsoleMember_019b4bf3-f02d-71b0-972c-d7306ea56022" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PCAndOtherProductsMember_019b4bf3-f02d-792e-9d18-815a04390e8d" xlink:href="ttwo-20251231.xsd#ttwo_PCAndOtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_PCAndOtherProductsMember_019b4bf3-f02d-792e-9d18-815a04390e8d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DigitalOnlineMember_019b4bf3-f02d-7d84-9900-e4f92289e50e" xlink:href="ttwo-20251231.xsd#ttwo_DigitalOnlineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_DigitalOnlineMember_019b4bf3-f02d-7d84-9900-e4f92289e50e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PhysicalRetailAndOtherMember_019b4bf3-f02d-7c34-b21f-5f9cd856f935" xlink:href="ttwo-20251231.xsd#ttwo_PhysicalRetailAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019b4bf3-f02d-74a1-ae64-eed2d98d728b" xlink:to="loc_ttwo_PhysicalRetailAndOtherMember_019b4bf3-f02d-7c34-b21f-5f9cd856f935" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f02d-72a4-9a68-95f81acb659c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_019b4bf3-f02d-7b16-b737-650b1cf9ed63" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f02d-72a4-9a68-95f81acb659c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019b4bf3-f02d-7108-a65d-e2a418d7ecfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019b4bf3-f02d-7108-a65d-e2a418d7ecfc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_019b4bf3-f02d-746c-b592-c7768f288aed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019b4bf3-f02d-7108-a65d-e2a418d7ecfc" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_019b4bf3-f02d-746c-b592-c7768f288aed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019b4bf3-f02d-7ca8-be0a-cc78b86ac205" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019b4bf3-f02d-7ca8-be0a-cc78b86ac205" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b4bf3-f02e-7706-b0b5-7de30512191c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b4bf3-f02e-7706-b0b5-7de30512191c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019b4bf3-f02e-7cc1-a1d0-c2273c87b163" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019b4bf3-f02e-7cc1-a1d0-c2273c87b163" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019b4bf3-f02e-7ed9-8309-c2c96578a768" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019b4bf3-f02e-7ed9-8309-c2c96578a768" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019b4bf3-f02e-7da4-97fd-7aed43fa7197" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019b4bf3-f02e-7da4-97fd-7aed43fa7197" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019b4bf3-f02e-7d91-8d43-e3d8ed969ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TradeReceivablesHeldForSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019b4bf3-f02e-7d91-8d43-e3d8ed969ec6" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="simple" xlink:href="ttwo-20251231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019b4bf3-f02d-7108-a65d-e2a418d7ecfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_019b4bf3-f02d-7108-a65d-e2a418d7ecfc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019b4bf3-f02d-7ca8-be0a-cc78b86ac205" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019b4bf3-f02d-7ca8-be0a-cc78b86ac205" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b4bf3-f02e-7706-b0b5-7de30512191c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b4bf3-f02e-7706-b0b5-7de30512191c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019b4bf3-f02e-7cc1-a1d0-c2273c87b163" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019b4bf3-f02e-7cc1-a1d0-c2273c87b163" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019b4bf3-f02e-7ed9-8309-c2c96578a768" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_019b4bf3-f02e-7ed9-8309-c2c96578a768" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019b4bf3-f02e-7da4-97fd-7aed43fa7197" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019b4bf3-f02e-7da4-97fd-7aed43fa7197" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019b4bf3-f02e-7d91-8d43-e3d8ed969ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TradeReceivablesHeldForSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_019b4bf3-f02d-76b3-99a0-ef2f804c6dee" xlink:to="loc_us-gaap_TradeReceivablesHeldForSaleAmount_019b4bf3-f02e-7d91-8d43-e3d8ed969ec6" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#MANAGEMENTAGREEMENTNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7825-98bc-92d310ba77d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7825-98bc-92d310ba77d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-7825-98bc-92d310ba77d2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7825-98bc-92d310ba77d2" xlink:to="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-7825-98bc-92d310ba77d2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-773f-ba4c-c0b289f4aeda" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7825-98bc-92d310ba77d2" xlink:to="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-773f-ba4c-c0b289f4aeda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZelnickMediaCorporationMember_019b4bf3-f02e-7d69-b1dc-6a669bdfe315" xlink:href="ttwo-20251231.xsd#ttwo_ZelnickMediaCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-773f-ba4c-c0b289f4aeda" xlink:to="loc_ttwo_ZelnickMediaCorporationMember_019b4bf3-f02e-7d69-b1dc-6a669bdfe315" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019b4bf3-f02e-7228-9f35-3f0c8dc63789" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019b4bf3-f02e-7228-9f35-3f0c8dc63789" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4bf3-f02e-7228-9f35-3f0c8dc63789_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b4bf3-f02e-7228-9f35-3f0c8dc63789" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4bf3-f02e-7228-9f35-3f0c8dc63789_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4bf3-f02e-7077-a222-1eeeeec046b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b4bf3-f02e-7228-9f35-3f0c8dc63789" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4bf3-f02e-7077-a222-1eeeeec046b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ManagementAgreement2022Member_019b4bf3-f02e-7d37-b096-ed1651be2a76" xlink:href="ttwo-20251231.xsd#ttwo_ManagementAgreement2022Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4bf3-f02e-7077-a222-1eeeeec046b9" xlink:to="loc_ttwo_ManagementAgreement2022Member_019b4bf3-f02e-7d37-b096-ed1651be2a76" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:to="loc_srt_RangeAxis_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa" xlink:to="loc_srt_RangeMember_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b4bf3-f02e-7406-a76c-6a16561bea63" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019b4bf3-f02e-7a9b-8b8c-54f5fe6e32fa" xlink:to="loc_srt_RangeMember_019b4bf3-f02e-7406-a76c-6a16561bea63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019b4bf3-f02e-72fa-803f-168a68d39bf5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019b4bf3-f02e-7406-a76c-6a16561bea63" xlink:to="loc_srt_MaximumMember_019b4bf3-f02e-72fa-803f-168a68d39bf5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-713c-aada-afae510f7f0b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7c5d-8852-f24b255f15b9" xlink:to="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-713c-aada-afae510f7f0b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-713c-aada-afae510f7f0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-713c-aada-afae510f7f0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-713c-aada-afae510f7f0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7a46-a6cd-3e8a9618630b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-713c-aada-afae510f7f0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7a46-a6cd-3e8a9618630b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019b4bf3-f02e-7d60-b99d-b683ffd34dfd" xlink:href="ttwo-20251231.xsd#ttwo_PerformanceBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7a46-a6cd-3e8a9618630b" xlink:to="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019b4bf3-f02e-7d60-b99d-b683ffd34dfd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MarketBasedRestrictedStockMember_019b4bf3-f02e-7544-813c-2e567ff7f4f4" xlink:href="ttwo-20251231.xsd#ttwo_MarketBasedRestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7a46-a6cd-3e8a9618630b" xlink:to="loc_ttwo_MarketBasedRestrictedStockMember_019b4bf3-f02e-7544-813c-2e567ff7f4f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019b4bf3-f02e-7b24-b64b-b59b2f765584" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7a46-a6cd-3e8a9618630b" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019b4bf3-f02e-7b24-b64b-b59b2f765584" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionAnnualManagementFee_019b4bf3-f02e-75fd-afac-92da0edbaff2" xlink:href="ttwo-20251231.xsd#ttwo_RelatedPartyTransactionAnnualManagementFee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_ttwo_RelatedPartyTransactionAnnualManagementFee_019b4bf3-f02e-75fd-afac-92da0edbaff2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionBonusPerFiscalYear_019b4bf3-f02e-7c5f-8a0f-a56eef20735c" xlink:href="ttwo-20251231.xsd#ttwo_RelatedPartyTransactionBonusPerFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_ttwo_RelatedPartyTransactionBonusPerFiscalYear_019b4bf3-f02e-7c5f-8a0f-a56eef20735c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RelatedPartyTransactionConsultingExpenseBenefit_019b4bf3-f02e-7c64-a30f-b87c9d1e7661" xlink:href="ttwo-20251231.xsd#ttwo_RelatedPartyTransactionConsultingExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_ttwo_RelatedPartyTransactionConsultingExpenseBenefit_019b4bf3-f02e-7c64-a30f-b87c9d1e7661" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_019b4bf3-f02e-7b85-b433-5d197db0735b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_019b4bf3-f02e-7b85-b433-5d197db0735b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod_019b4bf3-f02e-7e3d-8a97-4131ccf958b6" xlink:href="ttwo-20251231.xsd#ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardMeasurementPeriod_019b4bf3-f02e-7e3d-8a97-4131ccf958b6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement_019b4bf3-f02e-7c0a-b554-b0c944c3d0f4" xlink:href="ttwo-20251231.xsd#ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement_019b4bf3-f02e-7c0a-b554-b0c944c3d0f4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019b4bf3-f02e-78a3-9220-bfff19f08db0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_019b4bf3-f02e-78a3-9220-bfff19f08db0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019b4bf3-f02e-736d-a951-1a23a2fc4651" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019b4bf3-f02e-736d-a951-1a23a2fc4651" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019b4bf3-f02e-7b8e-8dc2-70490bcaac01" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019b4bf3-f02e-7b8e-8dc2-70490bcaac01" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019b4bf3-f02e-7c3d-bb27-099ae464b665" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-74ab-8aa5-132ea5db9486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019b4bf3-f02e-7c3d-bb27-099ae464b665" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTSharebasedPaymentArrangementRestrictedStockandRestrictedStockUnitActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-7af3-a907-10a7fb8cf1e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7b13-ad75-7c3cf1ddea80" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-7af3-a907-10a7fb8cf1e7" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7b13-ad75-7c3cf1ddea80" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-7969-bc19-42e5e2e91b5c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7b13-ad75-7c3cf1ddea80" xlink:to="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-7969-bc19-42e5e2e91b5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7969-bc19-42e5e2e91b5c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-7969-bc19-42e5e2e91b5c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-7969-bc19-42e5e2e91b5c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f02e-7969-bc19-42e5e2e91b5c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_TimeBasedRestrictedUnitsMember_019b4bf3-f02e-7a66-b755-d0f3fef8fb2f" xlink:href="ttwo-20251231.xsd#ttwo_TimeBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:to="loc_ttwo_TimeBasedRestrictedUnitsMember_019b4bf3-f02e-7a66-b755-d0f3fef8fb2f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MarketBasedRestrictedUnitsMember_019b4bf3-f02e-7cd3-bd22-5fde7c873e15" xlink:href="ttwo-20251231.xsd#ttwo_MarketBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:to="loc_ttwo_MarketBasedRestrictedUnitsMember_019b4bf3-f02e-7cd3-bd22-5fde7c873e15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019b4bf3-f02e-7441-bdf5-93e82c5f2028" xlink:href="ttwo-20251231.xsd#ttwo_PerformanceBasedRestrictedUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:to="loc_ttwo_PerformanceBasedRestrictedUnitsMember_019b4bf3-f02e-7441-bdf5-93e82c5f2028" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019b4bf3-f02e-7a84-bee9-96f8ea9e3b70" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f02e-774d-99ed-b6e69974b9a4" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019b4bf3-f02e-7a84-bee9-96f8ea9e3b70" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_019b4bf3-f02e-7b13-ad75-7c3cf1ddea80" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762" xlink:to="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-70d2-b2aa-675cde6573b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019b4bf3-f02e-7e20-bca7-b4d5bbdbb762" xlink:to="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-70d2-b2aa-675cde6573b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZelnickMediaCorporationMember_019b4bf3-f02e-74df-afdd-cb47301357d8" xlink:href="ttwo-20251231.xsd#ttwo_ZelnickMediaCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019b4bf3-f02e-70d2-b2aa-675cde6573b4" xlink:to="loc_ttwo_ZelnickMediaCorporationMember_019b4bf3-f02e-74df-afdd-cb47301357d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019b4bf3-f02e-717e-a7ab-854139e1554b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_019b4bf3-f02e-7af3-a907-10a7fb8cf1e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019b4bf3-f02e-717e-a7ab-854139e1554b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019b4bf3-f02e-7a50-8202-5d25bee15a80" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019b4bf3-f02e-73d0-8ef8-a7edd5828622" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019b4bf3-f02e-7a50-8202-5d25bee15a80" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019b4bf3-f02e-73d0-8ef8-a7edd5828622" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f02e-7ae3-adf1-2451a18807fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019b4bf3-f02e-73d0-8ef8-a7edd5828622" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f02e-7ae3-adf1-2451a18807fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7ae3-adf1-2451a18807fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f02e-7ae3-adf1-2451a18807fc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7ae3-adf1-2451a18807fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7605-b8ae-e4d07eeb67ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f02e-7ae3-adf1-2451a18807fc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7605-b8ae-e4d07eeb67ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019b4bf3-f02e-72d1-b4af-264cfcc593bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7605-b8ae-e4d07eeb67ab" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019b4bf3-f02e-72d1-b4af-264cfcc593bb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f02e-7e54-8f8c-02cea45847e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7605-b8ae-e4d07eeb67ab" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f02e-7e54-8f8c-02cea45847e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019b4bf3-f02e-7dc2-80b5-7404a23789d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f02e-7605-b8ae-e4d07eeb67ab" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019b4bf3-f02e-7dc2-80b5-7404a23789d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-70f3-92c1-b335066065a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019b4bf3-f02e-73d0-8ef8-a7edd5828622" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-70f3-92c1-b335066065a0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-70f3-92c1-b335066065a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-70f3-92c1-b335066065a0" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-70f3-92c1-b335066065a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-70f3-92c1-b335066065a0" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019b4bf3-f02e-7cdb-adcb-96ce44cd7bfa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:to="loc_us-gaap_BankTimeDepositsMember_019b4bf3-f02e-7cdb-adcb-96ce44cd7bfa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivateEquityFundsMember_019b4bf3-f02e-767b-8be7-f17c924d5d69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrivateEquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:to="loc_us-gaap_PrivateEquityFundsMember_019b4bf3-f02e-767b-8be7-f17c924d5d69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityFundsMember_019b4bf3-f02e-7f86-aad3-a3703c56213d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:to="loc_us-gaap_EquityFundsMember_019b4bf3-f02e-7f86-aad3-a3703c56213d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_019b4bf3-f02e-74ac-b4cd-a27c6d7f748e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7b26-91d5-fb90a37fd660" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_019b4bf3-f02e-74ac-b4cd-a27c6d7f748e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019b4bf3-f02e-73d0-8ef8-a7edd5828622" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7447-b5df-a59d6f3717f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019c0a5b-4c41-7d2f-8361-f7e0f7ce18da" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7447-b5df-a59d6f3717f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019b4bf3-f02e-7ddd-8ed2-730e28e79bcf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7447-b5df-a59d6f3717f6" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019b4bf3-f02e-7ddd-8ed2-730e28e79bcf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019c0a5c-0b94-74bb-aff8-68c642b4789a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c0a5b-4c41-7447-b5df-a59d6f3717f6" xlink:to="loc_us-gaap_BankTimeDepositsMember_019c0a5c-0b94-74bb-aff8-68c642b4789a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019b4bf3-f02e-7a50-8202-5d25bee15a80" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019b4bf3-f02e-75dd-bc1b-21dcfcf96179" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019b4bf3-f02e-75dd-bc1b-21dcfcf96179" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019b4bf3-f02e-76f1-81e1-1e796700f9d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_us-gaap_ShortTermInvestments_019b4bf3-f02e-76f1-81e1-1e796700f9d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashAtFairValue_019b4bf3-f02e-7e97-b030-30a2bc98ab3f" xlink:href="ttwo-20251231.xsd#ttwo_RestrictedCashAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_ttwo_RestrictedCashAtFairValue_019b4bf3-f02e-7e97-b030-30a2bc98ab3f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_019b4bf3-f02e-7b39-9718-ccc52a0ecc06" xlink:href="ttwo-20251231.xsd#ttwo_RestrictedCashNoncurrentFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_019b4bf3-f02e-7b39-9718-ccc52a0ecc06" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019b4bf3-f02e-73f1-b7e4-db45e548b902" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019b4bf3-f02e-73f1-b7e4-db45e548b902" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019b4bf3-f02e-7190-b278-238e9a7a7174" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019b4bf3-f02e-7fa5-b785-b815b83029fe" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019b4bf3-f02e-7190-b278-238e9a7a7174" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019b4bf3-f02e-7a50-8202-5d25bee15a80" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_019be8ed-ac2e-7f1c-9fd1-cd30e6e28304" xlink:href="ttwo-20251231.xsd#ttwo_ConvertibleDebtCurrentFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:to="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_019be8ed-ac2e-7f1c-9fd1-cd30e6e28304" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019b4bf3-f02e-721a-916c-09e6d63479de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:to="loc_us-gaap_DerivativeLiabilities_019b4bf3-f02e-721a-916c-09e6d63479de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConvertibleDebtNoncurrentFairValueDisclosures_019b4bf3-f02e-7613-92a4-d1393a098c34" xlink:href="ttwo-20251231.xsd#ttwo_ConvertibleDebtNoncurrentFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:to="loc_ttwo_ConvertibleDebtNoncurrentFairValueDisclosures_019b4bf3-f02e-7613-92a4-d1393a098c34" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_019b4bf3-f02e-743c-92f8-baf066a0dbca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_019b4bf3-f02e-7616-a7c0-76b6f72101eb" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_019b4bf3-f02e-743c-92f8-baf066a0dbca" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#SHORTTERMINVESTMENTSShorttermInvestmentsDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019b4bf3-f02e-76a6-a4f1-703628cc2c31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:to="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019b4bf3-f02e-76a6-a4f1-703628cc2c31" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-7d96-a76a-a94021d5a7b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfTradingSecuritiesAndOtherTradingAssetsTable_019b4bf3-f02e-76a6-a4f1-703628cc2c31" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-7d96-a76a-a94021d5a7b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7d96-a76a-a94021d5a7b3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-7d96-a76a-a94021d5a7b3" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7d96-a76a-a94021d5a7b3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7c86-9d84-e914bc74221a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019b4bf3-f02e-7d96-a76a-a94021d5a7b3" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7c86-9d84-e914bc74221a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019b4bf3-f02e-78e8-970c-2c2d81af643f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019b4bf3-f02e-7c86-9d84-e914bc74221a" xlink:to="loc_us-gaap_BankTimeDepositsMember_019b4bf3-f02e-78e8-970c-2c2d81af643f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019c0ae7-89c2-74a4-8933-1ec4d40bda24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:to="loc_us-gaap_ShortTermInvestments_019c0ae7-89c2-74a4-8933-1ec4d40bda24" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax_019c0ae7-89c2-7149-8775-1c1fef2dcf33" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:to="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedGainBeforeTax_019c0ae7-89c2-7149-8775-1c1fef2dcf33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax_019c0ae7-89c2-7468-96a6-50dee735bbbf" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:to="loc_ttwo_ShortTermInvestmentsAccumulatedGrossUnrealizedLossBeforeTax_019c0ae7-89c2-7468-96a6-50dee735bbbf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermInvestmentsFairValueDisclosure_019c0ae7-89c2-787a-9fb9-4b4cd1721597" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermInvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019b4bf3-f02e-7f6a-94c3-9f3401e9c280" xlink:to="loc_ttwo_ShortTermInvestmentsFairValueDisclosure_019c0ae7-89c2-787a-9fb9-4b4cd1721597" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019b4bf3-f02e-7eb3-8f3f-a51dad671263" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019b4bf3-f02e-7a67-a1b5-cb22aef90e04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019b4bf3-f02e-7eb3-8f3f-a51dad671263" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019b4bf3-f02e-7a67-a1b5-cb22aef90e04" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b4bf3-f02e-750d-81a2-8902ead799b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019b4bf3-f02e-7a67-a1b5-cb22aef90e04" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b4bf3-f02e-750d-81a2-8902ead799b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-750d-81a2-8902ead799b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b4bf3-f02e-750d-81a2-8902ead799b4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-750d-81a2-8902ead799b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-7b83-888b-9c2d0c2657c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b4bf3-f02e-750d-81a2-8902ead799b4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-7b83-888b-9c2d0c2657c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareInternalDevelopmentMember_019b4bf3-f02e-7fdf-964c-def2ffd650f0" xlink:href="ttwo-20251231.xsd#ttwo_SoftwareInternalDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-7b83-888b-9c2d0c2657c8" xlink:to="loc_ttwo_SoftwareInternalDevelopmentMember_019b4bf3-f02e-7fdf-964c-def2ffd650f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareExternalDevelopmentMember_019b4bf3-f02e-7da9-8be4-9f4303cd9316" xlink:href="ttwo-20251231.xsd#ttwo_SoftwareExternalDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-7b83-888b-9c2d0c2657c8" xlink:to="loc_ttwo_SoftwareExternalDevelopmentMember_019b4bf3-f02e-7da9-8be4-9f4303cd9316" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareLicensesMember_019b4bf3-f02e-7c1f-8556-12f216c3a789" xlink:href="ttwo-20251231.xsd#ttwo_SoftwareLicensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b4bf3-f02e-7b83-888b-9c2d0c2657c8" xlink:to="loc_ttwo_SoftwareLicensesMember_019b4bf3-f02e-7c1f-8556-12f216c3a789" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_019b4bf3-f02e-79be-bff2-a192be3c3527" xlink:href="ttwo-20251231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019b4bf3-f02e-7eb3-8f3f-a51dad671263" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_019b4bf3-f02e-79be-bff2-a192be3c3527" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_019b4bf3-f02e-7889-9c10-50e633d9a6b6" xlink:href="ttwo-20251231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019b4bf3-f02e-7eb3-8f3f-a51dad671263" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_019b4bf3-f02e-7889-9c10-50e633d9a6b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareImpairments1_019b4bf3-f02e-7e82-b243-c6c5b3e0fbb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CapitalizedComputerSoftwareImpairments1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019b4bf3-f02e-7eb3-8f3f-a51dad671263" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareImpairments1_019b4bf3-f02e-7e82-b243-c6c5b3e0fbb7" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTLongtermDebtNetDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f02e-781e-9fe0-b41be70f5499" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f02e-781e-9fe0-b41be70f5499" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-71dc-983b-2382ef975d71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f02e-781e-9fe0-b41be70f5499" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-71dc-983b-2382ef975d71" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71dc-983b-2382ef975d71_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-71dc-983b-2382ef975d71" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71dc-983b-2382ef975d71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-71dc-983b-2382ef975d71" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-77e5-b02e-733425007319" xlink:href="ttwo-20251231.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-77e5-b02e-733425007319" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-703b-bbe4-006871643512" xlink:href="ttwo-20251231.xsd#ttwo_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-703b-bbe4-006871643512" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-7099-820c-e1ccd4a0e480" xlink:href="ttwo-20251231.xsd#ttwo_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-7099-820c-e1ccd4a0e480" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-79b0-8b23-cab35b50fd5b" xlink:href="ttwo-20251231.xsd#ttwo_A2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-79b0-8b23-cab35b50fd5b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-75c0-b1ee-94d204bedb70" xlink:href="ttwo-20251231.xsd#ttwo_A2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-75c0-b1ee-94d204bedb70" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026ConvertibleNotesMember_019b4bf3-f0e9-7173-a011-7101d445d3d8" xlink:href="ttwo-20251231.xsd#ttwo_A2026ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-770c-a15e-bc6ba9d80a83" xlink:to="loc_ttwo_A2026ConvertibleNotesMember_019b4bf3-f0e9-7173-a011-7101d445d3d8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7410-997b-27d03c8ae1bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f02e-781e-9fe0-b41be70f5499" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7410-997b-27d03c8ae1bc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7410-997b-27d03c8ae1bc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7410-997b-27d03c8ae1bc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7410-997b-27d03c8ae1bc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-722d-abc7-a87642c594d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7410-997b-27d03c8ae1bc" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-722d-abc7-a87642c594d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f0e9-7b92-873b-a387abec8abb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-722d-abc7-a87642c594d0" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f0e9-7b92-873b-a387abec8abb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-78c4-8d72-73f91761749f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-78c4-8d72-73f91761749f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-7419-94f8-70c788b5dc4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-7419-94f8-70c788b5dc4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019b4bf3-f0e9-76e8-9c26-e880c8141b38" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019b4bf3-f0e9-76e8-9c26-e880c8141b38" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019b4bf3-f0e9-7e25-9012-4f5ec176fe1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-75d1-813d-ce6d4988a915" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019b4bf3-f0e9-7e25-9012-4f5ec176fe1d" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTShorttermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_019b4bf3-f0e9-7c54-83e6-4cae8ab5e2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShortTermDebtTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_019b4bf3-f0e9-7c54-83e6-4cae8ab5e2bb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_019b4bf3-f0e9-7c54-83e6-4cae8ab5e2bb" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-79cd-a47c-82d943bf6ac9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7c1c-96cd-7cd77bdc4072" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-79cd-a47c-82d943bf6ac9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2025ConvertibleNotesMember_019ba7e3-e9f3-7051-a095-b5e9338c3322" xlink:href="ttwo-20251231.xsd#ttwo_A2025ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-79cd-a47c-82d943bf6ac9" xlink:to="loc_ttwo_A2025ConvertibleNotesMember_019ba7e3-e9f3-7051-a095-b5e9338c3322" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-789a-b86f-f45cf781f6e1" xlink:href="ttwo-20251231.xsd#ttwo_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-79cd-a47c-82d943bf6ac9" xlink:to="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-789a-b86f-f45cf781f6e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026ConvertibleNotesMember_019be8fe-f754-7fae-a46b-434c6ed667e8" xlink:href="ttwo-20251231.xsd#ttwo_A2026ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-79cd-a47c-82d943bf6ac9" xlink:to="loc_ttwo_A2026ConvertibleNotesMember_019be8fe-f754-7fae-a46b-434c6ed667e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7d9c-ac82-76739e402275" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_019b4bf3-f0e9-7c54-83e6-4cae8ab5e2bb" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7d9c-ac82-76739e402275" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7d9c-ac82-76739e402275_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7d9c-ac82-76739e402275" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7d9c-ac82-76739e402275_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7aa0-b469-133410e1b07f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b4bf3-f0e9-7d9c-ac82-76739e402275" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7aa0-b469-133410e1b07f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f0e9-70b2-8562-41ca88719853" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b4bf3-f0e9-7aa0-b469-133410e1b07f" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019b4bf3-f0e9-70b2-8562-41ca88719853" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-70bd-bdb3-a4f9e89e2bd5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-70bd-bdb3-a4f9e89e2bd5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtGross_019b4bf3-f0e9-71c5-b24f-da293ea40354" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermDebtGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:to="loc_ttwo_ShortTermDebtGross_019b4bf3-f0e9-71c5-b24f-da293ea40354" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019b4bf3-f0e9-7b9f-9c10-7221bad26c6e" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:to="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019b4bf3-f0e9-7b9f-9c10-7221bad26c6e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019b4bf3-f0e9-772e-a216-ee382326eeb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7a08-aaa7-a49f24a76802" xlink:to="loc_us-gaap_ShortTermBorrowings_019b4bf3-f0e9-772e-a216-ee382326eeb2" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTInterestandOtherNetDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTInterestandOtherNetDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTInterestandOtherNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7716-a4c6-2cd32bc6fc9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-766a-acf6-79a94cee40c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7716-a4c6-2cd32bc6fc9d" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-766a-acf6-79a94cee40c4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-766a-acf6-79a94cee40c4" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7ed0-9f3b-ef76059a7f5f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2025NotesMember_019b4bf3-f0e9-7f6d-9cdd-baeadeabfef7" xlink:href="ttwo-20251231.xsd#ttwo_A2025NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2025NotesMember_019b4bf3-f0e9-7f6d-9cdd-baeadeabfef7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-7792-a06b-43195e7dcd79" xlink:href="ttwo-20251231.xsd#ttwo_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-7792-a06b-43195e7dcd79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-72f2-a422-412a2eabbc7d" xlink:href="ttwo-20251231.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-72f2-a422-412a2eabbc7d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-7b32-a1bf-e2f6b25491c3" xlink:href="ttwo-20251231.xsd#ttwo_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-7b32-a1bf-e2f6b25491c3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-7352-8058-e6a69381679c" xlink:href="ttwo-20251231.xsd#ttwo_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-7352-8058-e6a69381679c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-782a-ba86-6bcefc8f3aa1" xlink:href="ttwo-20251231.xsd#ttwo_A2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-782a-ba86-6bcefc8f3aa1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-7c9c-84c2-b78eae44f2c4" xlink:href="ttwo-20251231.xsd#ttwo_A2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-71e9-97d4-776775e78ddf" xlink:to="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-7c9c-84c2-b78eae44f2c4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_019b4bf3-f0e9-7f78-9294-52f8a9409b11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7716-a4c6-2cd32bc6fc9d" xlink:to="loc_us-gaap_InterestExpenseDebt_019b4bf3-f0e9-7f78-9294-52f8a9409b11" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTSeniorNotesDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTSeniorNotesDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTSeniorNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7672-8d62-d32293299c87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7c8d-b4fc-19f45af03de9" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7672-8d62-d32293299c87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZyngaIncMember_019b4bf3-f0e9-783f-bfca-e23403cdf842" xlink:href="ttwo-20251231.xsd#ttwo_ZyngaIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7672-8d62-d32293299c87" xlink:to="loc_ttwo_ZyngaIncMember_019b4bf3-f0e9-783f-bfca-e23403cdf842" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-76ce-a0db-0c8abd958547" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70bd-9ef6-78fd65f59abb" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-76ce-a0db-0c8abd958547" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019b4bf3-f0e9-7178-beed-7ead6479e9b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-76ce-a0db-0c8abd958547" xlink:to="loc_us-gaap_SeniorNotesMember_019b4bf3-f0e9-7178-beed-7ead6479e9b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_019b9e77-e9b8-7e22-a590-0b7b26561738" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-76ce-a0db-0c8abd958547" xlink:to="loc_us-gaap_LetterOfCreditMember_019b9e77-e9b8-7e22-a590-0b7b26561738" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7d16-a4c6-34afeb1072b0" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-755f-890e-479e22515072" xlink:href="ttwo-20251231.xsd#ttwo_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2029NotesMember_019b4bf3-f0e9-755f-890e-479e22515072" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-7c0b-a61c-3f39af39749c" xlink:href="ttwo-20251231.xsd#ttwo_A2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2034NotesMember_019b4bf3-f0e9-7c0b-a61c-3f39af39749c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2029And2034NotesMember_019b4bf3-f0e9-79f0-bcd7-2abde9f2f121" xlink:href="ttwo-20251231.xsd#ttwo_A2029And2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2029And2034NotesMember_019b4bf3-f0e9-79f0-bcd7-2abde9f2f121" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-7fa6-a3ab-2ffc299b9757" xlink:href="ttwo-20251231.xsd#ttwo_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2026NotesMember_019b4bf3-f0e9-7fa6-a3ab-2ffc299b9757" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-7b24-bb77-7ca162726e52" xlink:href="ttwo-20251231.xsd#ttwo_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2028NotesMember_019b4bf3-f0e9-7b24-bb77-7ca162726e52" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2024NotesMember_019b4bf3-f0e9-7fd2-9730-fc679a420213" xlink:href="ttwo-20251231.xsd#ttwo_A2024NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2024NotesMember_019b4bf3-f0e9-7fd2-9730-fc679a420213" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2025NotesMember_019b4bf3-f0e9-7074-b94a-be50f8151efc" xlink:href="ttwo-20251231.xsd#ttwo_A2025NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2025NotesMember_019b4bf3-f0e9-7074-b94a-be50f8151efc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-77a7-b63a-5d5da54574b9" xlink:href="ttwo-20251231.xsd#ttwo_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2027NotesMember_019b4bf3-f0e9-77a7-b63a-5d5da54574b9" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-7a4e-85d0-3a0240c738bc" xlink:href="ttwo-20251231.xsd#ttwo_A2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A2032NotesMember_019b4bf3-f0e9-7a4e-85d0-3a0240c738bc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A20252027And2032NotesMember_019b4bf3-f0e9-7e8b-bb51-e731cfa7baa3" xlink:href="ttwo-20251231.xsd#ttwo_A20252027And2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7d6a-86c6-dd5d655ef301" xlink:to="loc_ttwo_A20252027And2032NotesMember_019b4bf3-f0e9-7e8b-bb51-e731cfa7baa3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019b4bf3-f0e9-71b0-ae70-9af853875791" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7314-8967-5b1cfaa32c61" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019b4bf3-f0e9-71b0-ae70-9af853875791" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019b4bf3-f0e9-71b0-ae70-9af853875791_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019b4bf3-f0e9-71b0-ae70-9af853875791" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019b4bf3-f0e9-71b0-ae70-9af853875791_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019b4bf3-f0e9-7231-ac46-52c19d821116" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019b4bf3-f0e9-71b0-ae70-9af853875791" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019b4bf3-f0e9-7231-ac46-52c19d821116" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019b4bf3-f0e9-7cc8-bab6-5357181e4d66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019b4bf3-f0e9-7231-ac46-52c19d821116" xlink:to="loc_us-gaap_SeniorNotesMember_019b4bf3-f0e9-7cc8-bab6-5357181e4d66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019b4bf3-f0e9-7a65-9047-fbd3ec3ec6c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019b4bf3-f0e9-7a65-9047-fbd3ec3ec6c4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-7ef4-a89a-2d09adde28f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-7ef4-a89a-2d09adde28f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentPeriodicPaymentInterest_019b4bf3-f0e9-77b4-98a3-c5ed4067bd78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentPeriodicPaymentInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DebtInstrumentPeriodicPaymentInterest_019b4bf3-f0e9-77b4-98a3-c5ed4067bd78" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentChangeOfControlPurchasePricePercent_019b4bf3-f0e9-774b-b749-ef021ae156ee" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentChangeOfControlPurchasePricePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_ttwo_DebtInstrumentChangeOfControlPurchasePricePercent_019b4bf3-f0e9-774b-b749-ef021ae156ee" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentEventOfDefaultPercentOfPrincipalThreshold_019b4bf3-f0e9-7c6a-b322-d80d1523b7d6" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentEventOfDefaultPercentOfPrincipalThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_ttwo_DebtInstrumentEventOfDefaultPercentOfPrincipalThreshold_019b4bf3-f0e9-7c6a-b322-d80d1523b7d6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019b4bf3-f0e9-7918-afc9-24a426125e22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019b4bf3-f0e9-7918-afc9-24a426125e22" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_019b4bf3-f0e9-7820-ae4d-3684bbed00b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_019b4bf3-f0e9-7820-ae4d-3684bbed00b6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019b4bf3-f0e9-7298-922f-ed15a2781d6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019b4bf3-f0e9-7298-922f-ed15a2781d6c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_019b4bf3-f0e9-728f-9a64-1d8f54ac331b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_019b4bf3-f0e9-728f-9a64-1d8f54ac331b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019b4bf3-f0e9-7992-82c5-a2d6e4e3869d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7cd6-b1f7-3f5483fb763a" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019b4bf3-f0e9-7992-82c5-a2d6e4e3869d" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTCreditAgreementDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTCreditAgreementDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7008-8a09-eef98c921595" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7008-8a09-eef98c921595" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7008-8a09-eef98c921595_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7008-8a09-eef98c921595" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7008-8a09-eef98c921595_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7211-a1dd-cdcf02ee92d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7008-8a09-eef98c921595" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7211-a1dd-cdcf02ee92d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019b4bf3-f0e9-799f-97fd-f736003f7257" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7211-a1dd-cdcf02ee92d4" xlink:to="loc_us-gaap_LineOfCreditMember_019b4bf3-f0e9-799f-97fd-f736003f7257" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_019b4bf3-f0e9-78e6-9165-f822832b7cf7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7211-a1dd-cdcf02ee92d4" xlink:to="loc_us-gaap_LetterOfCreditMember_019b4bf3-f0e9-78e6-9165-f822832b7cf7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:to="loc_us-gaap_CreditFacilityAxis_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa" xlink:to="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-78da-9d48-e40729ea3c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_019b4bf3-f0e9-7fa0-b413-fab7bd88ffaa" xlink:to="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-78da-9d48-e40729ea3c5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_019b4bf3-f0e9-7a79-9a6f-6fadf61b81d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-78da-9d48-e40729ea3c5b" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_019b4bf3-f0e9-7a79-9a6f-6fadf61b81d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_019b4bf3-f0e9-7c4d-8a87-97a4f6123ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019b4bf3-f0e9-78da-9d48-e40729ea3c5b" xlink:to="loc_us-gaap_LetterOfCreditMember_019b4bf3-f0e9-7c4d-8a87-97a4f6123ce0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019b4bf3-f0e9-7c74-b9a3-79e911270dac" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:to="loc_srt_RangeAxis_019b4bf3-f0e9-7c74-b9a3-79e911270dac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b4bf3-f0e9-7c74-b9a3-79e911270dac_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019b4bf3-f0e9-7c74-b9a3-79e911270dac" xlink:to="loc_srt_RangeMember_019b4bf3-f0e9-7c74-b9a3-79e911270dac_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b4bf3-f0e9-7d6e-b51a-fbe7d6403ecf" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019b4bf3-f0e9-7c74-b9a3-79e911270dac" xlink:to="loc_srt_RangeMember_019b4bf3-f0e9-7d6e-b51a-fbe7d6403ecf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019b4bf3-f0e9-7e85-9e0c-981d1d729e1c" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019b4bf3-f0e9-7d6e-b51a-fbe7d6403ecf" xlink:to="loc_srt_MinimumMember_019b4bf3-f0e9-7e85-9e0c-981d1d729e1c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019b4bf3-f0e9-7bbf-af67-7bb99d2beed5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019b4bf3-f0e9-7d6e-b51a-fbe7d6403ecf" xlink:to="loc_srt_MaximumMember_019b4bf3-f0e9-7bbf-af67-7bb99d2beed5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_019b4bf3-f0e9-74ed-a489-7050e188069a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:to="loc_us-gaap_VariableRateAxis_019b4bf3-f0e9-74ed-a489-7050e188069a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-74ed-a489-7050e188069a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_019b4bf3-f0e9-74ed-a489-7050e188069a" xlink:to="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-74ed-a489-7050e188069a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-7ec1-91d2-22bcd918d6db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_019b4bf3-f0e9-74ed-a489-7050e188069a" xlink:to="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-7ec1-91d2-22bcd918d6db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_019b4bf3-f0e9-7486-b12f-8bffadad0f93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BaseRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-7ec1-91d2-22bcd918d6db" xlink:to="loc_us-gaap_BaseRateMember_019b4bf3-f0e9-7486-b12f-8bffadad0f93" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_019b4bf3-f0e9-7ddf-8593-690956753aea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SecuredOvernightFinancingRateSofrMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_019b4bf3-f0e9-7ec1-91d2-22bcd918d6db" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrMember_019b4bf3-f0e9-7ddf-8593-690956753aea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7de5-a588-cd6782dc0aae" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-74ba-bd74-5f82789d116a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7f80-a1fd-60d539d90b3e" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-74ba-bd74-5f82789d116a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2022CreditAgreementMember_019b4bf3-f0e9-742f-91c5-c3efadb47c53" xlink:href="ttwo-20251231.xsd#ttwo_A2022CreditAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-74ba-bd74-5f82789d116a" xlink:to="loc_ttwo_A2022CreditAgreementMember_019b4bf3-f0e9-742f-91c5-c3efadb47c53" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_019b4bf3-f0e9-7d4f-a33f-561ec32b0e9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DebtInstrumentTerm_019b4bf3-f0e9-7d4f-a33f-561ec32b0e9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019b4bf3-f0e9-79c3-9669-408b12a7bd0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019b4bf3-f0e9-79c3-9669-408b12a7bd0e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowings_019b4bf3-f0e9-7a03-80da-8da3eff4d2c2" xlink:href="ttwo-20251231.xsd#ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowings_019b4bf3-f0e9-7a03-80da-8da3eff4d2c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowingsPercent_019b4bf3-f0e9-772a-b538-9cf06cb25b60" xlink:href="ttwo-20251231.xsd#ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowingsPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_ttwo_LineOfCreditFacilityOptionalIncreaseAdditionalBorrowingsPercent_019b4bf3-f0e9-772a-b538-9cf06cb25b60" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentExtensionTerm_019b4bf3-f0e9-7d32-ad08-ef527e49053b" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentExtensionTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_ttwo_DebtInstrumentExtensionTerm_019b4bf3-f0e9-7d32-ad08-ef527e49053b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentNumberOfExtensions_019b4bf3-f0e9-7cfa-82de-1b76d99839ef" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentNumberOfExtensions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_ttwo_DebtInstrumentNumberOfExtensions_019b4bf3-f0e9-7cfa-82de-1b76d99839ef" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019b4bf3-f0e9-7dc7-b391-0541894de4e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019b4bf3-f0e9-7dc7-b391-0541894de4e0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019b4bf3-f0e9-79d8-94a6-063f5ded5981" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019b4bf3-f0e9-79d8-94a6-063f5ded5981" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019b4bf3-f0e9-770c-bf83-6a1ebfaedb69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019b4bf3-f0e9-770c-bf83-6a1ebfaedb69" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019b4bf3-f0e9-7eee-b4ca-704604c31699" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019b4bf3-f0e9-7eee-b4ca-704604c31699" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-712a-a3c3-3b052671df4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-712a-a3c3-3b052671df4c" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019b4bf3-f0e9-7020-8dfe-470fe16bc208" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-7957-83f3-81d576cfb9f8" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019b4bf3-f0e9-7020-8dfe-470fe16bc208" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTInformationRelatedtoAvailabilityonCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77e0-938f-8884a939bf89" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7304-bc22-b9a5c292610d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77e0-938f-8884a939bf89" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7304-bc22-b9a5c292610d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70ca-b050-90768d314c87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7304-bc22-b9a5c292610d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70ca-b050-90768d314c87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-70ca-b050-90768d314c87_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70ca-b050-90768d314c87" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-70ca-b050-90768d314c87_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-725a-b713-574ea9ae29a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-70ca-b050-90768d314c87" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-725a-b713-574ea9ae29a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019b4bf3-f0e9-7dfb-b597-880d20f3b4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-725a-b713-574ea9ae29a9" xlink:to="loc_us-gaap_LineOfCreditMember_019b4bf3-f0e9-7dfb-b597-880d20f3b4a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019b4bf3-f0e9-7d74-afc2-d37481599d7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77e0-938f-8884a939bf89" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_019b4bf3-f0e9-7d74-afc2-d37481599d7d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_019b4bf3-f0e9-7e62-bd50-8333f6963683" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77e0-938f-8884a939bf89" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_019b4bf3-f0e9-7e62-bd50-8333f6963683" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTConvertibleNotesDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#DEBTConvertibleNotesDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/DEBTConvertibleNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7e45-8d49-e44a44639813" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7e45-8d49-e44a44639813" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7e45-8d49-e44a44639813_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7e45-8d49-e44a44639813" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7e45-8d49-e44a44639813_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7da4-acef-1c173a8a6d02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019b4bf3-f0e9-7e45-8d49-e44a44639813" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7da4-acef-1c173a8a6d02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A025ConvertibleSeniorNotesDue2024Member_019b4bf3-f0e9-7de0-87cc-995813abd153" xlink:href="ttwo-20251231.xsd#ttwo_A025ConvertibleSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7da4-acef-1c173a8a6d02" xlink:to="loc_ttwo_A025ConvertibleSeniorNotesDue2024Member_019b4bf3-f0e9-7de0-87cc-995813abd153" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A0ConvertibleSeniorNotesDue2026Member_019b4bf3-f0e9-7e39-bdcd-a2dbeb924ace" xlink:href="ttwo-20251231.xsd#ttwo_A0ConvertibleSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7da4-acef-1c173a8a6d02" xlink:to="loc_ttwo_A0ConvertibleSeniorNotesDue2026Member_019b4bf3-f0e9-7e39-bdcd-a2dbeb924ace" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_A2026ConvertibleNotesMember_019b4bf3-f0e9-7649-b437-4618fe54d4c8" xlink:href="ttwo-20251231.xsd#ttwo_A2026ConvertibleNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019b4bf3-f0e9-7da4-acef-1c173a8a6d02" xlink:to="loc_ttwo_A2026ConvertibleNotesMember_019b4bf3-f0e9-7649-b437-4618fe54d4c8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7537-9354-82c06bbe93af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7537-9354-82c06bbe93af" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7537-9354-82c06bbe93af_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7537-9354-82c06bbe93af" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-7537-9354-82c06bbe93af_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-78d0-9e58-af9ed3805068" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b4bf3-f0e9-7537-9354-82c06bbe93af" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-78d0-9e58-af9ed3805068" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ZyngaIncMember_019b4bf3-f0e9-78ea-b4c5-9a84a045b685" xlink:href="ttwo-20251231.xsd#ttwo_ZyngaIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b4bf3-f0e9-78d0-9e58-af9ed3805068" xlink:to="loc_ttwo_ZyngaIncMember_019b4bf3-f0e9-78ea-b4c5-9a84a045b685" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7d0b-bee0-41c38ccafb23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019b4bf3-f0e9-7fe3-bc3a-747af721d7c5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7d0b-bee0-41c38ccafb23" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_019b4bf3-f0e9-7d5f-b4c3-beac166819b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019b4bf3-f0e9-7d0b-bee0-41c38ccafb23" xlink:to="loc_us-gaap_ConvertibleDebtMember_019b4bf3-f0e9-7d5f-b4c3-beac166819b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-77da-9ebb-e24d4fcb6806" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_019b4bf3-f0e9-7b55-a424-7ed3e114c7e1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-77da-9ebb-e24d4fcb6806" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_019b4bf3-f0e9-7048-a892-06556d1cec9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-77da-9ebb-e24d4fcb6806" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_019b4bf3-f0e9-7048-a892-06556d1cec9f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_019b4bf3-f0e9-735e-a3c4-c16359dbd39f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_019b4bf3-f0e9-77da-9ebb-e24d4fcb6806" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_019b4bf3-f0e9-735e-a3c4-c16359dbd39f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f0e9-714d-bf73-795bd9739d91" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f0e9-714d-bf73-795bd9739d91" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019b4bf3-f0e9-714d-bf73-795bd9739d91_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f0e9-714d-bf73-795bd9739d91" xlink:to="loc_us-gaap_EquityComponentDomain_019b4bf3-f0e9-714d-bf73-795bd9739d91_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019b4bf3-f0e9-724f-850f-3a08354f98c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019b4bf3-f0e9-714d-bf73-795bd9739d91" xlink:to="loc_us-gaap_EquityComponentDomain_019b4bf3-f0e9-724f-850f-3a08354f98c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019b4bf3-f0e9-7dff-9f1d-f616a907e87f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019b4bf3-f0e9-724f-850f-3a08354f98c1" xlink:to="loc_us-gaap_CommonStockMember_019b4bf3-f0e9-7dff-9f1d-f616a907e87f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019c0af5-3c87-72c9-bfed-114233ea6c58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019b4bf3-f0e9-7808-a264-074e3d1a03d2" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019c0af5-3c87-72c9-bfed-114233ea6c58" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019c0af5-3c87-72c9-bfed-114233ea6c58_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019c0af5-3c87-72c9-bfed-114233ea6c58" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019c0af5-3c87-72c9-bfed-114233ea6c58_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019c0af5-3c87-712b-9d77-0344c64d78ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019c0af5-3c87-72c9-bfed-114233ea6c58" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019c0af5-3c87-712b-9d77-0344c64d78ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_019c0af5-6e60-738c-ab83-f0bceb433e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019c0af5-3c87-712b-9d77-0344c64d78ad" xlink:to="loc_us-gaap_ConvertibleDebtMember_019c0af5-6e60-738c-ab83-f0bceb433e8f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-7bfa-9a98-e55971328c11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019b4bf3-f0e9-7bfa-9a98-e55971328c11" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019b4bf3-f0e9-7d8d-9150-07c741ad6b15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019b4bf3-f0e9-7d8d-9150-07c741ad6b15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019b4bf3-f0e9-76d8-a366-523b504c1304" xlink:href="ttwo-20251231.xsd#ttwo_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableEntitySharesIssuedPerAcquireeShare_019b4bf3-f0e9-76d8-a366-523b504c1304" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessAcquisitionCashPrice_019b4bf3-f0e9-7ceb-852b-e5950d7aa5ea" xlink:href="ttwo-20251231.xsd#ttwo_BusinessAcquisitionCashPrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_BusinessAcquisitionCashPrice_019b4bf3-f0e9-7ceb-852b-e5950d7aa5ea" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentConvertiblePrincipalTenderedForCash_019b4bf3-f0e9-705f-b495-0b36e6e786d2" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentConvertiblePrincipalTenderedForCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_DebtInstrumentConvertiblePrincipalTenderedForCash_019b4bf3-f0e9-705f-b495-0b36e6e786d2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtInstrumentConvertiblePrincipalConvertedIntoReferenceProperty_019b4bf3-f0e9-7b04-8679-580eaa6e40b2" xlink:href="ttwo-20251231.xsd#ttwo_DebtInstrumentConvertiblePrincipalConvertedIntoReferenceProperty"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_DebtInstrumentConvertiblePrincipalConvertedIntoReferenceProperty_019b4bf3-f0e9-7b04-8679-580eaa6e40b2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PaymentsForTenderedAndConvertedDebt_019b4bf3-f0e9-7e1e-bfdb-f4f494165fcb" xlink:href="ttwo-20251231.xsd#ttwo_PaymentsForTenderedAndConvertedDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_PaymentsForTenderedAndConvertedDebt_019b4bf3-f0e9-7e1e-bfdb-f4f494165fcb" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_019b4bf3-f0e9-76d2-84ce-c369cb132fc3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_019b4bf3-f0e9-76d2-84ce-c369cb132fc3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019b4bf3-f0e9-77f9-b318-abf3030e59e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_LongTermDebt_019b4bf3-f0e9-77f9-b318-abf3030e59e5" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_019b4bf3-f0e9-7bf8-8e7b-46aa03cce810" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_019b4bf3-f0e9-7bf8-8e7b-46aa03cce810" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_019b4bf3-f0e9-7a51-ba1c-d9c2e3bbd0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_019b4bf3-f0e9-7a51-ba1c-d9c2e3bbd0a9" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_019b4bf3-f0e9-7676-a257-9e26473ce741" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_019b4bf3-f0e9-7676-a257-9e26473ce741" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_019b4bf3-f0e9-7b63-aaed-74bb95312969" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_019b4bf3-f0e9-7b63-aaed-74bb95312969" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019b4bf3-f0e9-7626-b0b9-01a1d7d06e99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019b4bf3-f0e9-7626-b0b9-01a1d7d06e99" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-70dd-beca-d55a40316ed5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019b4bf3-f0e9-70dd-beca-d55a40316ed5" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtGross_019c0af4-2f30-79da-b9f0-1a1779857a1f" xlink:href="ttwo-20251231.xsd#ttwo_ShortTermDebtGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_ttwo_ShortTermDebtGross_019c0af4-2f30-79da-b9f0-1a1779857a1f" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019b4bf3-f0e9-7793-a6d3-1f92c4120402" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019b4bf3-f0e9-77c6-86c5-07f6ca69bda5" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019b4bf3-f0e9-7793-a6d3-1f92c4120402" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/LOSSPERSHARENarrativeDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#LOSSPERSHARENarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/LOSSPERSHARENarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b4bf3-f0e9-732c-ae18-cbd34f13be15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b4bf3-f0e9-732c-ae18-cbd34f13be15" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b4bf3-f0e9-75de-a6b9-71d7b5db389e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b4bf3-f0e9-732c-ae18-cbd34f13be15" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b4bf3-f0e9-75de-a6b9-71d7b5db389e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-75de-a6b9-71d7b5db389e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b4bf3-f0e9-75de-a6b9-71d7b5db389e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-75de-a6b9-71d7b5db389e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-738d-b406-bff156717bb6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b4bf3-f0e9-75de-a6b9-71d7b5db389e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-738d-b406-bff156717bb6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockCompensationPlanMember_019b4bf3-f0e9-7872-a4e3-ba0bee977643" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockCompensationPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-738d-b406-bff156717bb6" xlink:to="loc_us-gaap_StockCompensationPlanMember_019b4bf3-f0e9-7872-a4e3-ba0bee977643" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_019b4bf3-f0e9-7352-b847-208afcfb52ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b4bf3-f0e9-738d-b406-bff156717bb6" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_019b4bf3-f0e9-7352-b847-208afcfb52ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019b4bf3-f0e9-718b-9b51-a389f04dcd66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b4bf3-f0e9-732c-ae18-cbd34f13be15" xlink:to="loc_us-gaap_AwardTypeAxis_019b4bf3-f0e9-718b-9b51-a389f04dcd66" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f0e9-718b-9b51-a389f04dcd66_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f0e9-718b-9b51-a389f04dcd66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f0e9-718b-9b51-a389f04dcd66_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f0e9-719f-ba26-154e95d928c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019b4bf3-f0e9-718b-9b51-a389f04dcd66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f0e9-719f-ba26-154e95d928c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_019b4bf3-f0e9-79bc-a7d3-93d64af0e3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b4bf3-f0e9-719f-ba26-154e95d928c4" xlink:to="loc_us-gaap_RestrictedStockMember_019b4bf3-f0e9-79bc-a7d3-93d64af0e3a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019b4bf3-f0e9-7004-9866-653197fb7316" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b4bf3-f0e9-732c-ae18-cbd34f13be15" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019b4bf3-f0e9-7004-9866-653197fb7316" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b4bf3-f0e9-7004-9866-653197fb7316_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019b4bf3-f0e9-7004-9866-653197fb7316" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b4bf3-f0e9-7004-9866-653197fb7316_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b4bf3-f0e9-78a8-b7e4-6382a5952ace" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019b4bf3-f0e9-7004-9866-653197fb7316" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b4bf3-f0e9-78a8-b7e4-6382a5952ace" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PublicStockOfferingMember_019b4bf3-f0e9-7fd2-b9d2-b4e44df651b4" xlink:href="ttwo-20251231.xsd#ttwo_PublicStockOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b4bf3-f0e9-78a8-b7e4-6382a5952ace" xlink:to="loc_ttwo_PublicStockOfferingMember_019b4bf3-f0e9-7fd2-b9d2-b4e44df651b4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019b4bf3-f0e9-794e-af78-365718808d7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019b4bf3-f0e9-794e-af78-365718808d7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019b4bf3-f0e9-729c-901c-435ff9d5081a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019b4bf3-f0e9-729c-901c-435ff9d5081a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019b4bf3-f0e9-74be-a077-44cb0ba7041c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019b4bf3-f0e9-74be-a077-44cb0ba7041c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_019b4bf3-f0e9-7069-bb02-af2d888ba75d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_019b4bf3-f0e9-7069-bb02-af2d888ba75d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedStockAwardsReversalForfeitureAwards_019b4bf3-f0e9-7ca7-ba62-972debf527bb" xlink:href="ttwo-20251231.xsd#ttwo_RestrictedStockAwardsReversalForfeitureAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_ttwo_RestrictedStockAwardsReversalForfeitureAwards_019b4bf3-f0e9-7ca7-ba62-972debf527bb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ReversalOfCapitalizedCosts_019b4bf3-f0e9-7f04-992d-8fd75643c836" xlink:href="ttwo-20251231.xsd#ttwo_ReversalOfCapitalizedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_ttwo_ReversalOfCapitalizedCosts_019b4bf3-f0e9-7f04-992d-8fd75643c836" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019b4bf3-f0e9-7d57-a58a-9e9f3f9e66c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019b4bf3-f0e9-7d57-a58a-9e9f3f9e66c5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019b4bf3-f0e9-7f6b-8239-83b0ed86499e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019b4bf3-f0e9-7f6b-8239-83b0ed86499e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019b4bf3-f0e9-707c-9578-048501e3d98f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b4bf3-f0e9-7d95-91b4-b706e14422dc" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019b4bf3-f0e9-707c-9578-048501e3d98f" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONNetRevenuebyGeographicRegionsDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONNetRevenuebyGeographicRegionsDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/SEGMENTREPORTINGANDGEOGRAPHICINFORMATIONNetRevenuebyGeographicRegionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019b4bf3-f0e9-7ab7-af18-4ae6fd0a1fa3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019b4bf3-f0e9-7751-ac93-0b21106f6a9b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019b4bf3-f0e9-7ab7-af18-4ae6fd0a1fa3" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019b4bf3-f0e9-7751-ac93-0b21106f6a9b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019b4bf3-f0e9-727e-8208-9006d66081b6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019b4bf3-f0e9-7751-ac93-0b21106f6a9b" xlink:to="loc_srt_StatementGeographicalAxis_019b4bf3-f0e9-727e-8208-9006d66081b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-727e-8208-9006d66081b6_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019b4bf3-f0e9-727e-8208-9006d66081b6" xlink:to="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-727e-8208-9006d66081b6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-7492-9252-1458df4a84b5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019b4bf3-f0e9-727e-8208-9006d66081b6" xlink:to="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-7492-9252-1458df4a84b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019b4bf3-f0e9-7d2a-bc4f-48048f8ad6b9" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-7492-9252-1458df4a84b5" xlink:to="loc_country_US_019b4bf3-f0e9-7d2a-bc4f-48048f8ad6b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_019b4bf3-f0e9-770c-8874-548f38b192ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019b4bf3-f0e9-7492-9252-1458df4a84b5" xlink:to="loc_us-gaap_NonUsMember_019b4bf3-f0e9-770c-8874-548f38b192ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f0e9-7ccd-86ff-b758b0bbfd13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019b4bf3-f0e9-7ab7-af18-4ae6fd0a1fa3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b4bf3-f0e9-7ccd-86ff-b758b0bbfd13" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ASSETACQUISITIONNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#ASSETACQUISITIONNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/ASSETACQUISITIONNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionLineItems_019be932-ab4b-7aa8-93ff-c5b653b6dfd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_019be932-ab4a-7a4b-b1b2-4e7c0eda4a3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019be932-ab4b-7aa8-93ff-c5b653b6dfd4" xlink:to="loc_us-gaap_AssetAcquisitionTable_019be932-ab4a-7a4b-b1b2-4e7c0eda4a3e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019be932-ab4b-76da-b840-e12be802c513" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_019be932-ab4a-7a4b-b1b2-4e7c0eda4a3e" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019be932-ab4b-76da-b840-e12be802c513" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-76da-b840-e12be802c513_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019be932-ab4b-76da-b840-e12be802c513" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-76da-b840-e12be802c513_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-7ac2-b577-5b5522532ec9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019be932-ab4b-76da-b840-e12be802c513" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-7ac2-b577-5b5522532ec9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_LosAngelesBuildingAssetAcquisitionMember_019be932-ab4b-70ae-99f4-ef2ef40e8403" xlink:href="ttwo-20251231.xsd#ttwo_LosAngelesBuildingAssetAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-7ac2-b577-5b5522532ec9" xlink:to="loc_ttwo_LosAngelesBuildingAssetAcquisitionMember_019be932-ab4b-70ae-99f4-ef2ef40e8403" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_NewYorkOfficeSpaceAssetAcquisitionMember_019be932-ab4b-7ee2-8d44-d723484dcf21" xlink:href="ttwo-20251231.xsd#ttwo_NewYorkOfficeSpaceAssetAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019be932-ab4b-7ac2-b577-5b5522532ec9" xlink:to="loc_ttwo_NewYorkOfficeSpaceAssetAcquisitionMember_019be932-ab4b-7ee2-8d44-d723484dcf21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PaymentsForAssetAcquisitions_019be932-ab4b-740e-9897-78494e06a55b" xlink:href="ttwo-20251231.xsd#ttwo_PaymentsForAssetAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019be932-ab4b-7aa8-93ff-c5b653b6dfd4" xlink:to="loc_ttwo_PaymentsForAssetAcquisitions_019be932-ab4b-740e-9897-78494e06a55b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ASSETACQUISITIONScheduleofFairValueofacquiredTangibleAssetsDetails" xlink:type="simple" xlink:href="ttwo-20251231.xsd#ASSETACQUISITIONScheduleofFairValueofacquiredTangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.take2games.com/role/ASSETACQUISITIONScheduleofFairValueofacquiredTangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionLineItems_019be925-7d11-70c8-ae20-8fa231033dd3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_019be925-7d11-70e0-ae2c-17a80f108eec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019be925-7d11-70c8-ae20-8fa231033dd3" xlink:to="loc_us-gaap_AssetAcquisitionTable_019be925-7d11-70e0-ae2c-17a80f108eec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019be92c-fba1-71c1-a774-4fc61a66d7f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_019be925-7d11-70e0-ae2c-17a80f108eec" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019be92c-fba1-71c1-a774-4fc61a66d7f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019be92c-fba1-71c1-a774-4fc61a66d7f7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019be92c-fba1-71c1-a774-4fc61a66d7f7" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019be92c-fba1-71c1-a774-4fc61a66d7f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019be92c-fba1-7672-9304-3cc03e301811" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019be92c-fba1-71c1-a774-4fc61a66d7f7" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019be92c-fba1-7672-9304-3cc03e301811" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_LosAngelesBuildingAndNewYorkOfficeSpaceAssetAcquisitionMember_019be92d-b3f1-713b-8d5e-9440700d6a13" xlink:href="ttwo-20251231.xsd#ttwo_LosAngelesBuildingAndNewYorkOfficeSpaceAssetAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019be92c-fba1-7672-9304-3cc03e301811" xlink:to="loc_ttwo_LosAngelesBuildingAndNewYorkOfficeSpaceAssetAcquisitionMember_019be92d-b3f1-713b-8d5e-9440700d6a13" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019c012c-2db3-7364-be0a-918b7cbecaef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_019be925-7d11-70e0-ae2c-17a80f108eec" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019c012c-2db3-7364-be0a-918b7cbecaef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7364-be0a-918b7cbecaef_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019c012c-2db3-7364-be0a-918b7cbecaef" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7364-be0a-918b7cbecaef_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7b92-a051-71076b9f2346" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019c012c-2db3-7364-be0a-918b7cbecaef" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7b92-a051-71076b9f2346" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingMember_019c012c-2db3-7f59-9139-c0a2c3277b71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7b92-a051-71076b9f2346" xlink:to="loc_us-gaap_BuildingMember_019c012c-2db3-7f59-9139-c0a2c3277b71" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandMember_019c012c-2db3-7706-9e61-25d2ecfe1026" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LandMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019c012c-2db3-7b92-a051-71076b9f2346" xlink:to="loc_us-gaap_LandMember_019c012c-2db3-7706-9e61-25d2ecfe1026" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAdditions_019be925-7d11-7865-b493-8b60767620a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAdditions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019be925-7d11-70c8-ae20-8fa231033dd3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAdditions_019be925-7d11-7865-b493-8b60767620a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AcquiredLongLivedTangibleAssetsWeightedAverageUsefulLife_019be92b-fd75-7321-9369-7cd493559fa0" xlink:href="ttwo-20251231.xsd#ttwo_AcquiredLongLivedTangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019be925-7d11-70c8-ae20-8fa231033dd3" xlink:to="loc_ttwo_AcquiredLongLivedTangibleAssetsWeightedAverageUsefulLife_019be92b-fd75-7321-9369-7cd493559fa0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_StraussZelnickMember_019b4bf3-ef84-77e8-a29e-5c3bba83c68e" xlink:href="ttwo-20251231.xsd#ttwo_StraussZelnickMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_StraussZelnickMember_019b4bf3-ef84-77e8-a29e-5c3bba83c68e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_MichaelShereskyMember_019bfe75-2345-7d19-8097-236ead09e43c" xlink:href="ttwo-20251231.xsd#ttwo_MichaelShereskyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_MichaelShereskyMember_019bfe75-2345-7d19-8097-236ead09e43c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_KarlSlatoffMember_019b4bf3-eebb-7161-8bd3-38706d744ea8" xlink:href="ttwo-20251231.xsd#ttwo_KarlSlatoffMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_KarlSlatoffMember_019b4bf3-eebb-7161-8bd3-38706d744ea8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_WilliamBingGordonMember_019bfe81-78ed-774b-8eca-c45e2f595e44" xlink:href="ttwo-20251231.xsd#ttwo_WilliamBingGordonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ttwo_WilliamBingGordonMember_019bfe81-78ed-774b-8eca-c45e2f595e44" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
