<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:e37b2e8f-d4ad-4a53-ac8b-67cc4cdd5fb9,g:ed59579f-4127-402e-9085-17322a3fa775-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="ttwo-20241231.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_277fcf1a-5e64-4ad9-bdf4-3a131106f2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_AssetsCurrent_277fcf1a-5e64-4ad9-bdf4-3a131106f2c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_7fa11129-063b-43e3-b2e2-c5248476a958" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_7fa11129-063b-43e3-b2e2-c5248476a958" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_a7c0fba5-73bc-4526-9637-ae53bfe76782" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_Goodwill_a7c0fba5-73bc-4526-9637-ae53bfe76782" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_62cc92a1-0ee1-4981-8027-38d784a0010b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_62cc92a1-0ee1-4981-8027-38d784a0010b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_4f801115-fecd-4426-b0c6-933d54c6f937" xlink:href="ttwo-20241231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_4f801115-fecd-4426-b0c6-933d54c6f937" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_8e116463-a091-45ad-be99-524a62070b61" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_8e116463-a091-45ad-be99-524a62070b61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_fd24adc9-a99d-4c11-89fb-1d2131cbbb36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_fd24adc9-a99d-4c11-89fb-1d2131cbbb36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_634fdea4-cc16-4b92-bac7-404265d068b5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_83f360ad-619f-4912-aa44-3f7927224c0e" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_634fdea4-cc16-4b92-bac7-404265d068b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedRoyaltiesNoncurrent_3fec21da-4cdc-4891-adea-39f47d2a173a" xlink:href="ttwo-20241231.xsd#ttwo_AccruedRoyaltiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_ttwo_AccruedRoyaltiesNoncurrent_3fec21da-4cdc-4891-adea-39f47d2a173a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_ea758732-506e-4ecc-b05b-0e9bb053c1cf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_ea758732-506e-4ecc-b05b-0e9bb053c1cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_20d2d963-5de0-4e8f-b396-fa24316c358c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_LiabilitiesCurrent_20d2d963-5de0-4e8f-b396-fa24316c358c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_54794a2f-40a8-4863-96d6-74a3fe103bae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_54794a2f-40a8-4863-96d6-74a3fe103bae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_76c68e45-89fe-43d3-828d-d171415dbe6f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_76c68e45-89fe-43d3-828d-d171415dbe6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_abcb5707-f4a7-4159-97ef-93936e96258d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_abcb5707-f4a7-4159-97ef-93936e96258d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_1311ecbd-ecd7-4643-858a-57aedd79c0eb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_86ad9afb-ad65-4737-947d-def2597a4062" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_1311ecbd-ecd7-4643-858a-57aedd79c0eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_25c5618c-f1ef-4186-8c6b-a86aef94144b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_PreferredStockValue_25c5618c-f1ef-4186-8c6b-a86aef94144b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_8c578dd5-640f-4eb4-b62d-d00dcddfc5c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_CommonStockValue_8c578dd5-640f-4eb4-b62d-d00dcddfc5c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_c3e8380a-6381-41ee-8da6-2ecf4f1e9c5d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_TreasuryStockCommonValue_c3e8380a-6381-41ee-8da6-2ecf4f1e9c5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_dbef6ae1-42ae-4e53-aae5-f17704a0fe50" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_dbef6ae1-42ae-4e53-aae5-f17704a0fe50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_a8e8f3ce-0b56-4839-b03d-f360e230a353" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_a8e8f3ce-0b56-4839-b03d-f360e230a353" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1aa412fd-87cb-4702-9f06-f518a3ef15f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_613550c3-57ec-4763-a14b-128b04ac1578" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_1aa412fd-87cb-4702-9f06-f518a3ef15f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e98de851-ef37-4ac5-a2ec-c3737d2f9e29" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e98de851-ef37-4ac5-a2ec-c3737d2f9e29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_62fc82b8-e562-4268-9d8f-f9a92bf2ee0a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:to="loc_us-gaap_AccountsPayableCurrent_62fc82b8-e562-4268-9d8f-f9a92bf2ee0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_b837cac0-057b-44ce-89c5-6e1a27ec7f4d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_b837cac0-057b-44ce-89c5-6e1a27ec7f4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_777d2274-23e9-4854-a081-0ba8cb1d3f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_777d2274-23e9-4854-a081-0ba8cb1d3f8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_3738c211-78ca-46b0-a84f-577cbfb88b11" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3eeed355-210b-4bf5-930c-34b52724ce14" xlink:to="loc_us-gaap_ShortTermBorrowings_3738c211-78ca-46b0-a84f-577cbfb88b11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_57376913-3e71-4637-a00d-95c39bec2c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_57376913-3e71-4637-a00d-95c39bec2c1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_ef63d90a-9929-4edb-b9cd-15d89972d513" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_ShortTermInvestments_ef63d90a-9929-4edb-b9cd-15d89972d513" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_a63aba6f-7602-4ee9-be61-921a73c28603" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_a63aba6f-7602-4ee9-be61-921a73c28603" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_4fd6b76b-8166-4018-9600-31fd0bc70347" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_4fd6b76b-8166-4018-9600-31fd0bc70347" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_b0885a41-a0ed-4de5-af4c-7a98c7cdc489" xlink:href="ttwo-20241231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_b0885a41-a0ed-4de5-af4c-7a98c7cdc489" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c0b463c4-d376-4e20-a1de-219bcf5e61cd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c0b463c4-d376-4e20-a1de-219bcf5e61cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCostsCurrent_0fc37e4c-9cc6-4334-aad7-17f41cfc139c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredCostsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ac6cc7da-998c-4a1d-85cd-4a0740a4929a" xlink:to="loc_us-gaap_DeferredCostsCurrent_0fc37e4c-9cc6-4334-aad7-17f41cfc139c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_d13a37a4-ad95-45a6-8b84-0e4d3bc30ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_0d3302ff-18f6-4be4-a1d7-6c45b39c5aeb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d13a37a4-ad95-45a6-8b84-0e4d3bc30ac6" xlink:to="loc_us-gaap_StockholdersEquity_0d3302ff-18f6-4be4-a1d7-6c45b39c5aeb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_a1a42386-2dff-4acc-9cd5-727a63e064dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d13a37a4-ad95-45a6-8b84-0e4d3bc30ac6" xlink:to="loc_us-gaap_CommitmentsAndContingencies_a1a42386-2dff-4acc-9cd5-727a63e064dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c910e23a-3150-4551-9bed-a639afacc7ce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d13a37a4-ad95-45a6-8b84-0e4d3bc30ac6" xlink:to="loc_us-gaap_Liabilities_c910e23a-3150-4551-9bed-a639afacc7ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="simple" xlink:href="ttwo-20241231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_210fd402-88f0-4842-bae0-70ecdb40e645" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_30e04d2e-dc94-41fa-87c3-3f3f73936b6d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_210fd402-88f0-4842-bae0-70ecdb40e645" xlink:to="loc_us-gaap_GrossProfit_30e04d2e-dc94-41fa-87c3-3f3f73936b6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_e435f054-7c71-4e77-b635-52aad83c5644" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_210fd402-88f0-4842-bae0-70ecdb40e645" xlink:to="loc_us-gaap_OperatingExpenses_e435f054-7c71-4e77-b635-52aad83c5644" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4f83cefd-204f-49ac-b993-3c45c7bc1064" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_1bdcc4c3-efec-4c3e-8f17-a60fd05cc4fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4f83cefd-204f-49ac-b993-3c45c7bc1064" xlink:to="loc_us-gaap_OperatingIncomeLoss_1bdcc4c3-efec-4c3e-8f17-a60fd05cc4fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_318bfb21-a2e6-4f69-aa4f-ab5a21a45bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4f83cefd-204f-49ac-b993-3c45c7bc1064" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_318bfb21-a2e6-4f69-aa4f-ab5a21a45bc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_56ed8a10-8da1-40c3-b1bd-1470371e21bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4f83cefd-204f-49ac-b993-3c45c7bc1064" xlink:to="loc_us-gaap_GainLossOnInvestments_56ed8a10-8da1-40c3-b1bd-1470371e21bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_cf1e8471-2515-4e00-8336-f3a153e26223" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_SellingAndMarketingExpense_cf1e8471-2515-4e00-8336-f3a153e26223" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_8b58afa6-d3cd-40ff-a253-5a14fb150e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_8b58afa6-d3cd-40ff-a253-5a14fb150e7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_0474dd18-80e0-4be9-95bd-b80d6a89ab5b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_0474dd18-80e0-4be9-95bd-b80d6a89ab5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_519ae7d0-1dfa-449d-8492-1532bd9b5316" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_519ae7d0-1dfa-449d-8492-1532bd9b5316" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_1c671621-1fb7-4c77-9445-15f31802dfde" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_1c671621-1fb7-4c77-9445-15f31802dfde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_e81b3df6-d2d3-4023-8c16-3a836a073a92" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_bbb76d68-cb90-4e9b-8f88-9c6e8f8af746" xlink:to="loc_us-gaap_RestructuringCharges_e81b3df6-d2d3-4023-8c16-3a836a073a92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_69e08d97-2b4e-4dcc-8502-d11f51148fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e27ae60f-4d12-4740-b9fe-784c6db47ffb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_69e08d97-2b4e-4dcc-8502-d11f51148fc8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e27ae60f-4d12-4740-b9fe-784c6db47ffb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_e972b675-17db-4cbb-9542-c8d0380b3c1e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_69e08d97-2b4e-4dcc-8502-d11f51148fc8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_e972b675-17db-4cbb-9542-c8d0380b3c1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_8b6463f7-5654-4327-a108-1e561e5240db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_690a515a-35c2-4448-8684-ef34126bae7a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_8b6463f7-5654-4327-a108-1e561e5240db" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_690a515a-35c2-4448-8684-ef34126bae7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_a29233c6-0b55-411d-a0d1-e4716bfbb662" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_8b6463f7-5654-4327-a108-1e561e5240db" xlink:to="loc_us-gaap_CostOfRevenue_a29233c6-0b55-411d-a0d1-e4716bfbb662" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSSUnaudited" xlink:type="simple" xlink:href="ttwo-20241231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSSUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3e29b4d3-00cc-4a98-ab80-61315415d879" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_026cca40-e169-4be0-93ce-eea2808ba452" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3e29b4d3-00cc-4a98-ab80-61315415d879" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_026cca40-e169-4be0-93ce-eea2808ba452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_b4149a4b-9b0e-4293-8dd4-41b798b4dd25" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3e29b4d3-00cc-4a98-ab80-61315415d879" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_b4149a4b-9b0e-4293-8dd4-41b798b4dd25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_1bc3d633-3f72-481b-9767-aef5bb2cad84" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d8716418-7e29-4be3-8540-027d941ceb91" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_1bc3d633-3f72-481b-9767-aef5bb2cad84" xlink:to="loc_us-gaap_NetIncomeLoss_d8716418-7e29-4be3-8540-027d941ceb91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_aae9bd90-8a80-481d-b511-465413e13cc7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_1bc3d633-3f72-481b-9767-aef5bb2cad84" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_aae9bd90-8a80-481d-b511-465413e13cc7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="ttwo-20241231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_52aede96-1a93-4655-b3c3-eba3dd5e540c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_52aede96-1a93-4655-b3c3-eba3dd5e540c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_505f16df-1fad-4de3-9b95-cce8f172d296" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_505f16df-1fad-4de3-9b95-cce8f172d296" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_a35f5197-db26-47c2-9369-3cb7f173de00" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_a35f5197-db26-47c2-9369-3cb7f173de00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_69dfbb9b-5986-4912-bc59-110ada3da384" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_69dfbb9b-5986-4912-bc59-110ada3da384" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_d2352b88-acbd-4914-8f08-e1eae1f82caf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_d2352b88-acbd-4914-8f08-e1eae1f82caf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_dd2714c6-4d6d-41a8-af2a-48ae8079d2ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_dd2714c6-4d6d-41a8-af2a-48ae8079d2ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_bd55ba21-8aa2-461c-8802-3b0edba4a758" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireLongtermInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5268a753-75c7-4822-abf3-fcde54f90637" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_bd55ba21-8aa2-461c-8802-3b0edba4a758" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_eb49243e-f51b-46b2-a1a4-b3fedf410efb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_eb49243e-f51b-46b2-a1a4-b3fedf410efb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_PaymentForSettlementOfConvertibleNotes_5b0083df-fe2b-4780-88bc-c18fdd1b2443" xlink:href="ttwo-20241231.xsd#ttwo_PaymentForSettlementOfConvertibleNotes"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_ttwo_PaymentForSettlementOfConvertibleNotes_5b0083df-fe2b-4780-88bc-c18fdd1b2443" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_db0a85bd-a374-43de-8ef9-34492557302c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_db0a85bd-a374-43de-8ef9-34492557302c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_efad6c1e-3341-418a-89a0-085d453cacfb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_efad6c1e-3341-418a-89a0-085d453cacfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_18f9effa-8d5c-4ade-98b8-fdee28196917" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_18f9effa-8d5c-4ade-98b8-fdee28196917" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_a2d3d51e-4572-4f89-8734-0369af75f849" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_a2d3d51e-4572-4f89-8734-0369af75f849" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3c37cdaa-1473-4f84-a674-6fb4922b9ebe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a5f4d46e-e7dc-4862-9907-0da515e6d359" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3c37cdaa-1473-4f84-a674-6fb4922b9ebe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_685188bd-9d6c-47db-8756-af1ae370aa19" xlink:href="ttwo-20241231.xsd#ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_685188bd-9d6c-47db-8756-af1ae370aa19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_02d08950-e409-4fca-94a9-5b63966ade52" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_ShareBasedCompensation_02d08950-e409-4fca-94a9-5b63966ade52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfIntangibleAssets_7fa9d6c4-1f08-478e-b3ab-6b6115f5c703" xlink:href="ttwo-20241231.xsd#ttwo_AmortizationAndImpairmentOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_ttwo_AmortizationAndImpairmentOfIntangibleAssets_7fa9d6c4-1f08-478e-b3ab-6b6115f5c703" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_3f7cc22f-6f17-42e4-bcee-f1c26485e7d8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_3f7cc22f-6f17-42e4-bcee-f1c26485e7d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8fa3889d-ca42-45ce-b2f2-9955771ccce4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_NetIncomeLoss_8fa3889d-ca42-45ce-b2f2-9955771ccce4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_e0d0df5e-7b64-4538-9660-8ceee6f293ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_Depreciation_e0d0df5e-7b64-4538-9660-8ceee6f293ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_f93f5303-db78-41a3-bdc9-07ce2aa8f1e6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_f93f5303-db78-41a3-bdc9-07ce2aa8f1e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_937518f7-588f-44e6-b097-e2e2ef9f3035" xlink:href="ttwo-20241231.xsd#ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_937518f7-588f-44e6-b097-e2e2ef9f3035" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_36dbf67f-34b0-4a40-a163-88842d4b7ab4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_36dbf67f-34b0-4a40-a163-88842d4b7ab4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_InterestExpenseAndAmortizationOfDebtDiscountPremium_25365ba1-b6bb-4080-b653-e1fe58880138" xlink:href="ttwo-20241231.xsd#ttwo_InterestExpenseAndAmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_ttwo_InterestExpenseAndAmortizationOfDebtDiscountPremium_25365ba1-b6bb-4080-b653-e1fe58880138" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_8bc35999-1457-4f09-a53f-373deac722ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_8bc35999-1457-4f09-a53f-373deac722ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_7df03f99-26bd-47f7-9c42-5b1a0229cc3d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_7df03f99-26bd-47f7-9c42-5b1a0229cc3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_85e31487-c4bc-4e6c-8a50-7b6ad4f4e12e" xlink:href="ttwo-20241231.xsd#ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_85e31487-c4bc-4e6c-8a50-7b6ad4f4e12e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_98297289-f2cd-4959-aebe-0d92044ec6f0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_98297289-f2cd-4959-aebe-0d92044ec6f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d0deac75-04e7-4302-8926-a3802a44c9dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d0deac75-04e7-4302-8926-a3802a44c9dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_4ed1a54e-5141-47e5-b6e2-e5ccdd03f03a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2a2f0934-74ef-4449-92a3-1f8495e7e89b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_4ed1a54e-5141-47e5-b6e2-e5ccdd03f03a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_db9947a8-ecdd-4b76-96ff-1c8706c374b6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a6e939a7-fa93-4501-9d5d-ae04a68269c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_db9947a8-ecdd-4b76-96ff-1c8706c374b6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a6e939a7-fa93-4501-9d5d-ae04a68269c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b2c88456-8e13-44aa-95f9-f0b8952707de" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_db9947a8-ecdd-4b76-96ff-1c8706c374b6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b2c88456-8e13-44aa-95f9-f0b8952707de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_81e59b80-73e7-4b64-aa7a-e29eee4d4b76" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_db9947a8-ecdd-4b76-96ff-1c8706c374b6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_81e59b80-73e7-4b64-aa7a-e29eee4d4b76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c0b4b03d-c10c-476f-bbb0-43fc5204af3a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_db9947a8-ecdd-4b76-96ff-1c8706c374b6" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c0b4b03d-c10c-476f-bbb0-43fc5204af3a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSSegregationofAllAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_ddd244e4-88fb-4836-84de-0f3a27ea2ba1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:to="loc_us-gaap_ShortTermInvestments_ddd244e4-88fb-4836-84de-0f3a27ea2ba1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_2b12f19b-48dd-46c3-a00a-cbe8bc7c89f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_2b12f19b-48dd-46c3-a00a-cbe8bc7c89f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashAtFairValue_251b5f11-872c-472e-8cfd-40db6da31c9b" xlink:href="ttwo-20241231.xsd#ttwo_RestrictedCashAtFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:to="loc_ttwo_RestrictedCashAtFairValue_251b5f11-872c-472e-8cfd-40db6da31c9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_a27f5563-2f24-484f-88a3-360d405598a3" xlink:href="ttwo-20241231.xsd#ttwo_RestrictedCashNoncurrentFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:to="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_a27f5563-2f24-484f-88a3-360d405598a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_2c3abfa4-c476-417f-ad5e-f02794173aee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_6aa4af72-4ca5-45df-a89d-4d8e59269687" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_2c3abfa4-c476-417f-ad5e-f02794173aee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_c10547e8-a66e-4868-afde-e1fb3bb1e9ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_2575a37b-5660-4c6b-8384-58383e6534df" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_c10547e8-a66e-4868-afde-e1fb3bb1e9ac" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_2575a37b-5660-4c6b-8384-58383e6534df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_b8d024da-f9e3-4422-a712-33f1e61c4f00" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_c10547e8-a66e-4868-afde-e1fb3bb1e9ac" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_b8d024da-f9e3-4422-a712-33f1e61c4f00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_90b468c6-2b93-48b4-a490-4dc26d3724cf" xlink:href="ttwo-20241231.xsd#ttwo_ConvertibleDebtCurrentFairValueDisclosures"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_c10547e8-a66e-4868-afde-e1fb3bb1e9ac" xlink:to="loc_ttwo_ConvertibleDebtCurrentFairValueDisclosures_90b468c6-2b93-48b4-a490-4dc26d3724cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ConvertibleDebtNoncurrentFairValueDisclosures_565761f9-57ef-4189-ad15-5086c464e800" xlink:href="ttwo-20241231.xsd#ttwo_ConvertibleDebtNoncurrentFairValueDisclosures"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_c10547e8-a66e-4868-afde-e1fb3bb1e9ac" xlink:to="loc_ttwo_ConvertibleDebtNoncurrentFairValueDisclosures_565761f9-57ef-4189-ad15-5086c464e800" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#SHORTTERMINVESTMENTSShorttermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSShorttermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_94fd34c5-4f68-4b7f-bcb1-f797acea56b9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6dfd1258-77ec-43ec-a373-803d9142d4a9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_94fd34c5-4f68-4b7f-bcb1-f797acea56b9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6dfd1258-77ec-43ec-a373-803d9142d4a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c65b6d4c-da84-4ce1-a62a-f491f3f77403" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_94fd34c5-4f68-4b7f-bcb1-f797acea56b9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c65b6d4c-da84-4ce1-a62a-f491f3f77403" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f209d5fc-4409-427b-b991-598ad62748b7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_94fd34c5-4f68-4b7f-bcb1-f797acea56b9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f209d5fc-4409-427b-b991-598ad62748b7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesofShorttermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#SHORTTERMINVESTMENTSContractedMaturitiesofShorttermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesofShorttermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_194ea506-7192-46b3-8037-688205e76cc6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_b57aacb8-8e1e-4ee6-82bd-16da96a2fdcc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_194ea506-7192-46b3-8037-688205e76cc6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_b57aacb8-8e1e-4ee6-82bd-16da96a2fdcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_37aca148-dabc-4071-b740-76c20d51b5fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_08f4c89c-e90b-427a-9d42-f13121e3495a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_37aca148-dabc-4071-b740-76c20d51b5fc" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_08f4c89c-e90b-427a-9d42-f13121e3495a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DeferredAcquisitionPaymentsCurrent_c84db8c8-3795-4dd4-95b2-72b3a56cf238" xlink:href="ttwo-20241231.xsd#ttwo_DeferredAcquisitionPaymentsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_ttwo_DeferredAcquisitionPaymentsCurrent_c84db8c8-3795-4dd4-95b2-72b3a56cf238" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_1f08a412-7f4e-4006-9e65-ed3df419bf46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_1f08a412-7f4e-4006-9e65-ed3df419bf46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_96589092-ea02-42bf-be91-c04843b2ea05" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_96589092-ea02-42bf-be91-c04843b2ea05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_202b3d6d-ddd1-446b-9e69-3996d4f6d836" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_202b3d6d-ddd1-446b-9e69-3996d4f6d836" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedLicensesCurrent_19de80ba-aa94-46bb-9539-bfb73e89def1" xlink:href="ttwo-20241231.xsd#ttwo_AccruedLicensesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_ttwo_AccruedLicensesCurrent_19de80ba-aa94-46bb-9539-bfb73e89def1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesAndExciseTaxPayableCurrent_f15226e5-128c-4ae0-839b-9ac1dd0f5dec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SalesAndExciseTaxPayableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_SalesAndExciseTaxPayableCurrent_f15226e5-128c-4ae0-839b-9ac1dd0f5dec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_86cbabe5-e636-43f2-aa73-c5772461f4f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_86cbabe5-e636-43f2-aa73-c5772461f4f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SettlementLiabilitiesCurrent_dd257d6d-ea48-4538-a429-fc23905604a2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SettlementLiabilitiesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_SettlementLiabilitiesCurrent_dd257d6d-ea48-4538-a429-fc23905604a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_5389bdf5-4b07-463f-b54e-1e76ae3cada4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_TaxesPayableCurrent_5389bdf5-4b07-463f-b54e-1e76ae3cada4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_8dcca449-309f-41aa-93c9-74232d6228a5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_InterestPayableCurrent_8dcca449-309f-41aa-93c9-74232d6228a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRefundLiabilityCurrent_b5f95881-4892-4998-b1c0-442b1f6f0d34" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_CustomerRefundLiabilityCurrent_b5f95881-4892-4998-b1c0-442b1f6f0d34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4d9dc957-dea6-4f55-9e9a-309e771c0a79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_1b5d309d-cd20-44fc-8a6d-9ec9709226bc" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4d9dc957-dea6-4f55-9e9a-309e771c0a79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#DEBTLongtermDebtNetDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTLongtermDebtNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_e31ab49a-4437-445b-8016-d5ae3c27b058" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_a3fa2a63-a09e-463e-9645-29fc33fa8a33" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_e31ab49a-4437-445b-8016-d5ae3c27b058" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_a3fa2a63-a09e-463e-9645-29fc33fa8a33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_d52e34d9-e1aa-4d69-a5b5-54429cac4f38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_e31ab49a-4437-445b-8016-d5ae3c27b058" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_d52e34d9-e1aa-4d69-a5b5-54429cac4f38" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#DEBTShorttermDebtDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTShorttermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_7eb0e037-76d7-4efb-9390-4d0319cdac66" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_a2ddf5fe-391f-431b-8feb-a4b77abafd1d" xlink:href="ttwo-20241231.xsd#ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_7eb0e037-76d7-4efb-9390-4d0319cdac66" xlink:to="loc_ttwo_ShortTermDebtUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_a2ddf5fe-391f-431b-8feb-a4b77abafd1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_ShortTermDebtGross_da4b184f-ccf9-4ae4-a933-2f71ac47af7f" xlink:href="ttwo-20241231.xsd#ttwo_ShortTermDebtGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_7eb0e037-76d7-4efb-9390-4d0319cdac66" xlink:to="loc_ttwo_ShortTermDebtGross_da4b184f-ccf9-4ae4-a933-2f71ac47af7f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTDebtMaturitiesDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#DEBTDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:href="ttwo-20241231.xsd#ttwo_DebtGrossBeforeFairValueAdjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityRemainderOfFiscalYear_005b9aec-0b20-4782-af24-9dafac4e5d9d" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityRemainderOfFiscalYear_005b9aec-0b20-4782-af24-9dafac4e5d9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityYearThree_367a6f42-38b7-4ee3-95bb-0acd81894782" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityYearThree_367a6f42-38b7-4ee3-95bb-0acd81894782" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityYearFour_ddc1385a-1d2d-429c-9fac-25f0a9eec0dc" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityYearFour_ddc1385a-1d2d-429c-9fac-25f0a9eec0dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityAfterYearFour_855536c1-3e3a-4fbe-998b-e4b7669e669c" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityAfterYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityAfterYearFour_855536c1-3e3a-4fbe-998b-e4b7669e669c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityYearOne_18ce2bd4-9e95-4d38-97f4-b9a9b0c5bc86" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityYearOne"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityYearOne_18ce2bd4-9e95-4d38-97f4-b9a9b0c5bc86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtMaturityYearTwo_d2fbaae9-8218-4ccd-b39c-16350259d50a" xlink:href="ttwo-20241231.xsd#ttwo_DebtMaturityYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ttwo_DebtGrossBeforeFairValueAdjustments_bba4a361-b4e2-46a0-9470-b3e5204efbe3" xlink:to="loc_ttwo_DebtMaturityYearTwo_d2fbaae9-8218-4ccd-b39c-16350259d50a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_af4a1a71-ddc8-4520-95b8-5545defc480d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtGrossBeforeFairValueAdjustments_6e0af0bd-5be6-410a-8a13-a09b08970494" xlink:href="ttwo-20241231.xsd#ttwo_DebtGrossBeforeFairValueAdjustments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_af4a1a71-ddc8-4520-95b8-5545defc480d" xlink:to="loc_ttwo_DebtGrossBeforeFairValueAdjustments_6e0af0bd-5be6-410a-8a13-a09b08970494" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtFairValueAdjustments_0211b7a5-0295-468e-9a23-38d87e456c41" xlink:href="ttwo-20241231.xsd#ttwo_DebtFairValueAdjustments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_af4a1a71-ddc8-4520-95b8-5545defc480d" xlink:to="loc_ttwo_DebtFairValueAdjustments_0211b7a5-0295-468e-9a23-38d87e456c41" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSAcquisitiondateFairValueoftheConsiderationDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#ACQUISITIONSAcquisitiondateFairValueoftheConsiderationDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSAcquisitiondateFairValueoftheConsiderationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_76be68a5-8206-4c00-abbf-09863faa1a47" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessCombinationConsiderationTransferredSettlement_220a78e2-fa6d-4353-989c-53897d0bf6ea" xlink:href="ttwo-20241231.xsd#ttwo_BusinessCombinationConsiderationTransferredSettlement"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_76be68a5-8206-4c00-abbf-09863faa1a47" xlink:to="loc_ttwo_BusinessCombinationConsiderationTransferredSettlement_220a78e2-fa6d-4353-989c-53897d0bf6ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessCombinationConsiderationTransferredDeferredPayment_b21148ed-a537-4acf-abfb-68c4a06ff5e6" xlink:href="ttwo-20241231.xsd#ttwo_BusinessCombinationConsiderationTransferredDeferredPayment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_76be68a5-8206-4c00-abbf-09863faa1a47" xlink:to="loc_ttwo_BusinessCombinationConsiderationTransferredDeferredPayment_b21148ed-a537-4acf-abfb-68c4a06ff5e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_79f27616-7f9a-41c9-903d-155d44126c2e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_76be68a5-8206-4c00-abbf-09863faa1a47" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_79f27616-7f9a-41c9-903d-155d44126c2e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#ACQUISITIONSRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSRecognizedIdentifiedAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_e5a3175c-66e9-471f-ac41-ccfa8f3ff893" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_e5a3175c-66e9-471f-ac41-ccfa8f3ff893" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_49ff3206-b48f-4726-9438-0333b88e2c70" xlink:href="ttwo-20241231.xsd#ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets_49ff3206-b48f-4726-9438-0333b88e2c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_a52efe63-40f0-416f-aea7-cf559da40712" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_us-gaap_Goodwill_a52efe63-40f0-416f-aea7-cf559da40712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_9ae49c92-bad6-46f3-b330-0693af9fc426" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_9ae49c92-bad6-46f3-b330-0693af9fc426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_c9ac8909-2632-4499-b910-274fb7770ecf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_c9ac8909-2632-4499-b910-274fb7770ecf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_c2209d12-d856-42cd-8bc7-0c769b993d72" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a3fb67d2-cf45-4345-94ff-ca979fca8000" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_c2209d12-d856-42cd-8bc7-0c769b993d72" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/GOODWILLANDINTANGIBLEASSETSNETChangeinGoodwillBalanceDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#GOODWILLANDINTANGIBLEASSETSNETChangeinGoodwillBalanceDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/GOODWILLANDINTANGIBLEASSETSNETChangeinGoodwillBalanceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2b37d581-dc52-4b5a-8d64-fd0e8262623c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_14268072-f12f-4bd9-b2db-7e89782d38d1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Goodwill_2b37d581-dc52-4b5a-8d64-fd0e8262623c" xlink:to="loc_us-gaap_GoodwillGross_14268072-f12f-4bd9-b2db-7e89782d38d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_7ae105a2-092f-4f67-8d71-8f55d6a5f732" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Goodwill_2b37d581-dc52-4b5a-8d64-fd0e8262623c" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_7ae105a2-092f-4f67-8d71-8f55d6a5f732" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/GOODWILLANDINTANGIBLEASSETSNETIntangibleAssetsSubjecttoAmortizationDetails" xlink:type="simple" xlink:href="ttwo-20241231.xsd#GOODWILLANDINTANGIBLEASSETSNETIntangibleAssetsSubjecttoAmortizationDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/GOODWILLANDINTANGIBLEASSETSNETIntangibleAssetsSubjecttoAmortizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_8745f539-2186-42f7-83e1-ce5961912c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2fd92b9e-09dd-4f28-951e-8006898b1713" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_8745f539-2186-42f7-83e1-ce5961912c0b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2fd92b9e-09dd-4f28-951e-8006898b1713" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_0ad89a48-0008-46fb-843a-fdf73bb96e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_8745f539-2186-42f7-83e1-ce5961912c0b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_0ad89a48-0008-46fb-843a-fdf73bb96e8c" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
