<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:2fd6809b-135d-42cc-a551-e76b43073cee,g:2612ff55-ccec-4fff-afb0-dcd35af763cf-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.take2games.com/role/COVER" xlink:type="simple" xlink:href="ttwo-20201231.xsd#COVER"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/COVER" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_5c120116-b941-45af-b48a-e3d331124219" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_PreferredStockValue_5c120116-b941-45af-b48a-e3d331124219" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_e732b04d-b93d-488b-bcf9-2cf78624e7d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_CommonStockValue_e732b04d-b93d-488b-bcf9-2cf78624e7d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_7386e54d-834e-4f85-86fb-cc5e8ee4abc0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_7386e54d-834e-4f85-86fb-cc5e8ee4abc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2db348f6-6d01-468a-bf79-dcd062487729" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2db348f6-6d01-468a-bf79-dcd062487729" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_b1087521-f96e-4197-b5d3-d7580f64ddc1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_TreasuryStockValue_b1087521-f96e-4197-b5d3-d7580f64ddc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d323b62a-4a82-4359-9e56-141be5f702b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2cb00948-e796-4d88-80c0-3788e9fa4d4e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d323b62a-4a82-4359-9e56-141be5f702b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_bedb0d2b-6e91-4df5-b260-ecc4822c263c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8cba97c0-81c2-4e10-aceb-11f89ce1204f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_bedb0d2b-6e91-4df5-b260-ecc4822c263c" xlink:to="loc_us-gaap_Liabilities_8cba97c0-81c2-4e10-aceb-11f89ce1204f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4ed2084d-a912-4b99-b5e6-676292720595" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_bedb0d2b-6e91-4df5-b260-ecc4822c263c" xlink:to="loc_us-gaap_StockholdersEquity_4ed2084d-a912-4b99-b5e6-676292720595" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_f9b28067-78c7-436a-b3d6-30a211b3dd2b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_bedb0d2b-6e91-4df5-b260-ecc4822c263c" xlink:to="loc_us-gaap_CommitmentsAndContingencies_f9b28067-78c7-436a-b3d6-30a211b3dd2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_f12cecdc-91b3-4c88-9a73-dd994697e800" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_f563c597-d18b-43a6-82ac-43e071d581ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f12cecdc-91b3-4c88-9a73-dd994697e800" xlink:to="loc_us-gaap_AccountsPayableCurrent_f563c597-d18b-43a6-82ac-43e071d581ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_f15d8129-2ba4-4c37-b502-2108bd58c3b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f12cecdc-91b3-4c88-9a73-dd994697e800" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_f15d8129-2ba4-4c37-b502-2108bd58c3b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1fa2a4a2-25a2-4762-96a0-eb7dd312df92" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f12cecdc-91b3-4c88-9a73-dd994697e800" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1fa2a4a2-25a2-4762-96a0-eb7dd312df92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_9ad80822-c359-4dc1-abcd-e20975d0f3bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f12cecdc-91b3-4c88-9a73-dd994697e800" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_9ad80822-c359-4dc1-abcd-e20975d0f3bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_822e8b2d-3daf-4358-8639-3e7cb7563fc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_AssetsCurrent_822e8b2d-3daf-4358-8639-3e7cb7563fc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_1407c028-ef82-4123-82db-7c8178accf82" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_1407c028-ef82-4123-82db-7c8178accf82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_7d07d6d3-1245-49c9-84d3-b07ce09d1b1c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_Goodwill_7d07d6d3-1245-49c9-84d3-b07ce09d1b1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bed13c12-19a7-4257-991d-8a00d3bab13a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bed13c12-19a7-4257-991d-8a00d3bab13a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_d2010f2d-259c-4d19-8024-79c9fa3a3705" xlink:href="ttwo-20201231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_d2010f2d-259c-4d19-8024-79c9fa3a3705" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_3bd95fbb-329b-490a-a31f-d24e9b4a8c38" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_3bd95fbb-329b-490a-a31f-d24e9b4a8c38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_184c1230-f887-450f-90c5-000a7de0ce15" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_184c1230-f887-450f-90c5-000a7de0ce15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_6d7086a1-d2be-4795-8f88-9c392a05a616" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_6d7086a1-d2be-4795-8f88-9c392a05a616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_e009bd8d-108b-429c-8ac2-5061bd788cef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3daccfa1-14ca-4116-b40f-ed135c639e08" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_e009bd8d-108b-429c-8ac2-5061bd788cef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_bf6fdc8b-ff8d-41d0-a9c6-15eb5a79c6f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:to="loc_us-gaap_LiabilitiesCurrent_bf6fdc8b-ff8d-41d0-a9c6-15eb5a79c6f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_d7924272-e3aa-40a8-b963-9e2a5f464460" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_d7924272-e3aa-40a8-b963-9e2a5f464460" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_c9604402-6feb-4d05-95c5-fecbc5f8c1e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_c9604402-6feb-4d05-95c5-fecbc5f8c1e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedRoyaltiesNoncurrent_bab868a6-7029-4a95-a690-68b5a1d5643f" xlink:href="ttwo-20201231.xsd#ttwo_AccruedRoyaltiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:to="loc_ttwo_AccruedRoyaltiesNoncurrent_bab868a6-7029-4a95-a690-68b5a1d5643f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_5b8ac849-5a27-41e5-8612-8b908024129f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d9cfd10-cc00-4448-bef2-ac8632e8e12a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_5b8ac849-5a27-41e5-8612-8b908024129f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_bba38a62-da46-4113-a97e-db8c18d49a94" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_bba38a62-da46-4113-a97e-db8c18d49a94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_aeb3babf-a598-446f-b320-20d9f75647ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_ShortTermInvestments_aeb3babf-a598-446f-b320-20d9f75647ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_83e2d48e-3ec5-49b0-b96a-c05090d28b4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_83e2d48e-3ec5-49b0-b96a-c05090d28b4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_105cdb4b-95f9-4e6f-91e0-de277a953849" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_105cdb4b-95f9-4e6f-91e0-de277a953849" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_126df3c9-3e62-487f-9da9-4ccb26dc4510" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_InventoryNet_126df3c9-3e62-487f-9da9-4ccb26dc4510" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_3e99754c-9cda-49fc-8907-84953c07fee7" xlink:href="ttwo-20201231.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_3e99754c-9cda-49fc-8907-84953c07fee7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCostsCurrent_d19004c0-6234-4816-8381-588fa1051ee8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredCostsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_DeferredCostsCurrent_d19004c0-6234-4816-8381-588fa1051ee8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_76bbf36f-0946-4dcf-9969-688b5e96a963" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_72d576ca-e557-4032-87fb-a42a52138a61" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_76bbf36f-0946-4dcf-9969-688b5e96a963" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_62db79c1-9de8-40a1-9b58-d7f240ac18dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5874c826-b459-4bfc-87c0-ae3a7f9a9521" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_62db79c1-9de8-40a1-9b58-d7f240ac18dc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5874c826-b459-4bfc-87c0-ae3a7f9a9521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_d33dc59d-6ded-4c66-8201-e0c92174cbeb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_62db79c1-9de8-40a1-9b58-d7f240ac18dc" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_d33dc59d-6ded-4c66-8201-e0c92174cbeb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a8d3ce8d-54b0-4c7f-a412-c85280eba25f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_6830ce35-e8af-40d6-b4ac-d25a6a4fb4d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a8d3ce8d-54b0-4c7f-a412-c85280eba25f" xlink:to="loc_us-gaap_GrossProfit_6830ce35-e8af-40d6-b4ac-d25a6a4fb4d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_07cef117-b8f4-4403-becd-243ab4b4b228" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a8d3ce8d-54b0-4c7f-a412-c85280eba25f" xlink:to="loc_us-gaap_OperatingExpenses_07cef117-b8f4-4403-becd-243ab4b4b228" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c40f9de9-4d05-46d1-9c96-f21e0a3c901b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_0dd2ce51-a71b-47ed-8515-2e50e66972b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c40f9de9-4d05-46d1-9c96-f21e0a3c901b" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_0dd2ce51-a71b-47ed-8515-2e50e66972b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_9ea1013a-d556-4c4c-afc8-29af4e79a0f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c40f9de9-4d05-46d1-9c96-f21e0a3c901b" xlink:to="loc_us-gaap_OperatingIncomeLoss_9ea1013a-d556-4c4c-afc8-29af4e79a0f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_adf7d220-0ad1-4dec-b09b-202b7077eed4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c40f9de9-4d05-46d1-9c96-f21e0a3c901b" xlink:to="loc_us-gaap_GainLossOnInvestments_adf7d220-0ad1-4dec-b09b-202b7077eed4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d922e31e-e918-45d3-b96b-bf4aa1d2244d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3487aee8-6cd6-4619-aeb3-adc30fa50167" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d922e31e-e918-45d3-b96b-bf4aa1d2244d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3487aee8-6cd6-4619-aeb3-adc30fa50167" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_14f39ac6-0856-4ae6-a946-4c6cd45e7aef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d922e31e-e918-45d3-b96b-bf4aa1d2244d" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_14f39ac6-0856-4ae6-a946-4c6cd45e7aef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_b2682b75-8519-4594-be4f-3ca9d7b3e6e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:to="loc_us-gaap_SellingAndMarketingExpense_b2682b75-8519-4594-be4f-3ca9d7b3e6e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_4ce19d1a-e4bd-4c61-985d-e13d9de0706b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_4ce19d1a-e4bd-4c61-985d-e13d9de0706b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_d0b4ff2c-85e4-4591-8b98-27ba28986f1b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_d0b4ff2c-85e4-4591-8b98-27ba28986f1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_25284369-9b3f-4d30-b110-655c0a8e5daa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:to="loc_us-gaap_RestructuringCharges_25284369-9b3f-4d30-b110-655c0a8e5daa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_6f6420d7-48bc-4c06-aeee-5fa7bc1e0bbf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_0f0473f9-0308-486d-ba6d-22db52ee0080" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_6f6420d7-48bc-4c06-aeee-5fa7bc1e0bbf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2b552d86-e9a9-4ffc-ba20-7fc37858ed2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_392eafb3-5643-449d-a148-0ad58b326a39" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2b552d86-e9a9-4ffc-ba20-7fc37858ed2a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_392eafb3-5643-449d-a148-0ad58b326a39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_9dca427f-b8c3-45b7-a723-7aaf8e7925ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2b552d86-e9a9-4ffc-ba20-7fc37858ed2a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_9dca427f-b8c3-45b7-a723-7aaf8e7925ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_a45a8e70-52e7-403d-9bc5-270e4298c3a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2b552d86-e9a9-4ffc-ba20-7fc37858ed2a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_a45a8e70-52e7-403d-9bc5-270e4298c3a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_49b5f9ac-3a2d-4de0-b415-a23cfaee85b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1d88e529-f0d0-4b26-8f3b-01a38342f136" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_49b5f9ac-3a2d-4de0-b415-a23cfaee85b5" xlink:to="loc_us-gaap_NetIncomeLoss_1d88e529-f0d0-4b26-8f3b-01a38342f136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_dc29baad-3fc9-462a-9562-0cfc9a653e5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_49b5f9ac-3a2d-4de0-b415-a23cfaee85b5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_dc29baad-3fc9-462a-9562-0cfc9a653e5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_5b9174c3-de72-421a-a118-4d509180b5dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ec7ad6df-362a-4b3a-bcfd-f9b703b5d47a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_5b9174c3-de72-421a-a118-4d509180b5dd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ec7ad6df-362a-4b3a-bcfd-f9b703b5d47a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_23e14700-f27f-4935-bbb6-ff2832528b98" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_5b9174c3-de72-421a-a118-4d509180b5dd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_23e14700-f27f-4935-bbb6-ff2832528b98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent_ad4bff19-6c02-462f-b8ba-20699f074dee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_5b9174c3-de72-421a-a118-4d509180b5dd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent_ad4bff19-6c02-462f-b8ba-20699f074dee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_7e6a4819-562b-4932-a629-e40ea4e3d0cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_NetIncomeLoss_7e6a4819-562b-4932-a629-e40ea4e3d0cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_253cd8a8-0088-41e5-a89d-aefed18c873c" xlink:href="ttwo-20201231.xsd#ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_253cd8a8-0088-41e5-a89d-aefed18c873c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_91c35103-79c7-45b4-916a-555a2fe65ddb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_Depreciation_91c35103-79c7-45b4-916a-555a2fe65ddb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfIntellectualProperty_c328791b-2d7b-45f1-ba1a-41bedc448fdd" xlink:href="ttwo-20201231.xsd#ttwo_AmortizationAndImpairmentOfIntellectualProperty"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_ttwo_AmortizationAndImpairmentOfIntellectualProperty_c328791b-2d7b-45f1-ba1a-41bedc448fdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_9f36772a-68aa-41d5-9ca8-49a8377236f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_ShareBasedCompensation_9f36772a-68aa-41d5-9ca8-49a8377236f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_GainLossOnInvestmentsGross_b5fab42a-39a5-4112-b894-90bc7a2a26bd" xlink:href="ttwo-20201231.xsd#ttwo_GainLossOnInvestmentsGross"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_ttwo_GainLossOnInvestmentsGross_b5fab42a-39a5-4112-b894-90bc7a2a26bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_c31b15eb-cb7d-4b2c-9d77-c6dbe49ca229" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_c31b15eb-cb7d-4b2c-9d77-c6dbe49ca229" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_04bdf99f-4af8-4f8a-9f90-5bb2f518b665" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_04bdf99f-4af8-4f8a-9f90-5bb2f518b665" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_d06749ce-d392-4bed-8f10-55725966e311" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_d06749ce-d392-4bed-8f10-55725966e311" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_b0850410-dd27-4602-acf8-806c519718f8" xlink:href="ttwo-20201231.xsd#ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_b0850410-dd27-4602-acf8-806c519718f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_fa88d5ae-cf25-4f69-b20e-d58bea7b184d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_fa88d5ae-cf25-4f69-b20e-d58bea7b184d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_836751c4-ece1-4ec8-ad34-3e65868c12ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_836751c4-ece1-4ec8-ad34-3e65868c12ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredCharges_04488c37-f8f5-4f36-bb89-5846ce898b75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredCharges"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredCharges_04488c37-f8f5-4f36-bb89-5846ce898b75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_24243d61-d730-4c8b-8a91-72594c51a5b6" xlink:href="ttwo-20201231.xsd#ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6dbd0e8e-99e4-4e5e-84d1-fc46bbbd523c" xlink:to="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_24243d61-d730-4c8b-8a91-72594c51a5b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9370b8c4-b592-4814-804a-5a1c570358b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3c38ba06-92fa-4611-88c8-4414e9570d25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9370b8c4-b592-4814-804a-5a1c570358b9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3c38ba06-92fa-4611-88c8-4414e9570d25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_17358300-bc06-42fc-ba57-13f4fda52618" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9370b8c4-b592-4814-804a-5a1c570358b9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_17358300-bc06-42fc-ba57-13f4fda52618" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3639630f-43d4-4976-9fee-d442a9733e21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9370b8c4-b592-4814-804a-5a1c570358b9" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3639630f-43d4-4976-9fee-d442a9733e21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a8107b4b-e1e5-4823-a943-fff684ff5725" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9370b8c4-b592-4814-804a-5a1c570358b9" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a8107b4b-e1e5-4823-a943-fff684ff5725" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_99fdd693-ddcc-4303-a10e-e89dd8d25306" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_aefb52e6-25e5-4ff5-a96d-8e8c8a6b944e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_99fdd693-ddcc-4303-a10e-e89dd8d25306" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_aefb52e6-25e5-4ff5-a96d-8e8c8a6b944e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d9ed9f94-2137-4547-a63a-48f2c329cbc9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_99fdd693-ddcc-4303-a10e-e89dd8d25306" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d9ed9f94-2137-4547-a63a-48f2c329cbc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_c17244c4-42d7-47ad-a3cb-0ad0609d3a6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_c17244c4-42d7-47ad-a3cb-0ad0609d3a6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_96a04a57-d1a3-4b96-9e5a-7149ab8e6404" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_96a04a57-d1a3-4b96-9e5a-7149ab8e6404" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_daeaa5fb-0a72-4341-95fc-88f76fb55069" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_daeaa5fb-0a72-4341-95fc-88f76fb55069" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_3222dcb4-f71e-40c5-90c9-b175c92ce351" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_3222dcb4-f71e-40c5-90c9-b175c92ce351" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_82d931fd-89e9-4769-9e1e-f2b6d0e8362a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfLongtermInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_82d931fd-89e9-4769-9e1e-f2b6d0e8362a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_020c5865-4820-43e9-9f61-e8e08b5244d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireLongtermInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_020c5865-4820-43e9-9f61-e8e08b5244d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_59fae6a4-060a-4fce-864f-cf9f8a8e0048" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d175b7cb-bcaf-411c-be08-4937bbc4a176" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_59fae6a4-060a-4fce-864f-cf9f8a8e0048" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited" xlink:type="simple" xlink:href="ttwo-20201231.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="simple" xlink:href="ttwo-20201231.xsd#BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="simple" xlink:href="ttwo-20201231.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENT" xlink:type="simple" xlink:href="ttwo-20201231.xsd#MANAGEMENTAGREEMENT"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENT" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#MANAGEMENTAGREEMENTTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#MANAGEMENTAGREEMENTDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#FAIRVALUEMEASUREMENTS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#FAIRVALUEMEASUREMENTSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSRecurringFairValueMeasurementsDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#FAIRVALUEMEASUREMENTSRecurringFairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSRecurringFairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueNetAssetLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashAtFairValue_f4e70b33-0435-4a8d-8fc7-d7b693220883" xlink:href="ttwo-20201231.xsd#ttwo_RestrictedCashAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_ttwo_RestrictedCashAtFairValue_f4e70b33-0435-4a8d-8fc7-d7b693220883" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f1f39a47-7ac7-4067-a1c2-da0ea41d71d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f1f39a47-7ac7-4067-a1c2-da0ea41d71d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_98e21b9c-e3a5-4c0a-ae90-365096d5a79c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_us-gaap_ShortTermInvestments_98e21b9c-e3a5-4c0a-ae90-365096d5a79c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_7126db0f-7133-4379-8143-8d1df55c9bc9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_us-gaap_DerivativeAssets_7126db0f-7133-4379-8143-8d1df55c9bc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_d610b7bd-2117-4488-9dd6-362000ded1a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_d610b7bd-2117-4488-9dd6-362000ded1a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_8867dbe3-bf3c-43f3-81f7-f7991a53ae7c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_us-gaap_DerivativeLiabilities_8867dbe3-bf3c-43f3-81f7-f7991a53ae7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_e40003ce-bb26-47a4-a3b1-beb253a803eb" xlink:href="ttwo-20201231.xsd#ttwo_RestrictedCashNoncurrentFairValueDisclosure"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_f9a6e0de-8260-425b-ab73-433e25fac298" xlink:to="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_e40003ce-bb26-47a4-a3b1-beb253a803eb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#FAIRVALUEMEASUREMENTSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SHORTTERMINVESTMENTS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SHORTTERMINVESTMENTSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSScheduleofShortTermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SHORTTERMINVESTMENTSScheduleofShortTermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSScheduleofShortTermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_86a4a089-51c9-42ab-92c3-076d24c9737b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_a3daac88-f7d1-45aa-97b0-53a7938c52d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_86a4a089-51c9-42ab-92c3-076d24c9737b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_a3daac88-f7d1-45aa-97b0-53a7938c52d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9020e27c-de58-4b4e-8ee7-79ad75ab8803" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_86a4a089-51c9-42ab-92c3-076d24c9737b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9020e27c-de58-4b4e-8ee7-79ad75ab8803" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4088a76d-d9b7-40a1-a03e-466f4bb9ddf5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_86a4a089-51c9-42ab-92c3-076d24c9737b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4088a76d-d9b7-40a1-a03e-466f4bb9ddf5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesofShortTermInvestmentsDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SHORTTERMINVESTMENTSContractedMaturitiesofShortTermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesofShortTermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f7d1c146-9301-4430-b2ed-b0ca6bc6fd4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_880f2706-e49a-4dd8-bdcf-ca63ad329efe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f7d1c146-9301-4430-b2ed-b0ca6bc6fd4d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_880f2706-e49a-4dd8-bdcf-ca63ad329efe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_bc1ebb04-0092-4987-8ed0-e663d0b228fb" xlink:href="ttwo-20201231.xsd#ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f7d1c146-9301-4430-b2ed-b0ca6bc6fd4d" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_bc1ebb04-0092-4987-8ed0-e663d0b228fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_6fbd85b0-8015-4896-af56-cd6e948b12c0" xlink:href="ttwo-20201231.xsd#ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f7d1c146-9301-4430-b2ed-b0ca6bc6fd4d" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_6fbd85b0-8015-4896-af56-cd6e948b12c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01f073a9-d986-405e-9d0e-e778745ca71b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_d34b8dfd-faa3-4cb7-a153-e2e45f366fb4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01f073a9-d986-405e-9d0e-e778745ca71b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_d34b8dfd-faa3-4cb7-a153-e2e45f366fb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_041f71b8-1c84-40a4-9327-d0e8ec7a2e88" xlink:href="ttwo-20201231.xsd#ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01f073a9-d986-405e-9d0e-e778745ca71b" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_041f71b8-1c84-40a4-9327-d0e8ec7a2e88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_146a2e7a-b54c-45cb-9225-98e429e3a4a7" xlink:href="ttwo-20201231.xsd#ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_01f073a9-d986-405e-9d0e-e778745ca71b" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_146a2e7a-b54c-45cb-9225-98e429e3a4a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORY" xlink:type="simple" xlink:href="ttwo-20201231.xsd#INVENTORY"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORYTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#INVENTORYTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORYTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORYDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#INVENTORYDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORYDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_5806c2a0-b9a7-4d38-8fcc-b39e9490d8f0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_d98a77e1-9cd8-4518-a234-0cff4e7e312c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_5806c2a0-b9a7-4d38-8fcc-b39e9490d8f0" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_d98a77e1-9cd8-4518-a234-0cff4e7e312c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_aa6584bc-c668-42da-8afa-2d7a0312672d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_5806c2a0-b9a7-4d38-8fcc-b39e9490d8f0" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_aa6584bc-c668-42da-8afa-2d7a0312672d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_27bcbbe4-4284-4d90-923b-79bba056685b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_27bcbbe4-4284-4d90-923b-79bba056685b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_89c5f773-d379-4f7b-965a-36ede14356f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_89c5f773-d379-4f7b-965a-36ede14356f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedLicensesCurrent_b18708be-bb74-4366-beb1-89dff27ac6dc" xlink:href="ttwo-20201231.xsd#ttwo_AccruedLicensesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_ttwo_AccruedLicensesCurrent_b18708be-bb74-4366-beb1-89dff27ac6dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_15f8443d-3e9a-479c-a545-9e2fe2635f49" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_15f8443d-3e9a-479c-a545-9e2fe2635f49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e5212300-4704-4fd5-955c-2eb4d482ce91" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e5212300-4704-4fd5-955c-2eb4d482ce91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRefundLiabilityCurrent_be8ab9c2-6c86-4c41-8639-992248bb0323" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_ebbd659d-80a2-4ac1-ab7b-544a72c06db5" xlink:to="loc_us-gaap_CustomerRefundLiabilityCurrent_be8ab9c2-6c86-4c41-8639-992248bb0323" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBT" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DEBT"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBT" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DEBTTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#DEBTDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#EARNINGSPERSHAREEPS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#EARNINGSPERSHAREEPSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSScheduleofEarningsPerShareDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#EARNINGSPERSHAREEPSScheduleofEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSScheduleofEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4bf775bf-a5a6-4aed-ba34-ac6743bdffa6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet_c90dfc89-ea41-42be-af02-25a3b1f03810" xlink:href="ttwo-20201231.xsd#ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4bf775bf-a5a6-4aed-ba34-ac6743bdffa6" xlink:to="loc_ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet_c90dfc89-ea41-42be-af02-25a3b1f03810" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_13599af2-b3ff-4a1a-9566-ca6cf4a6cdee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4bf775bf-a5a6-4aed-ba34-ac6743bdffa6" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_13599af2-b3ff-4a1a-9566-ca6cf4a6cdee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#EARNINGSPERSHAREEPSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#COMMITMENTSANDCONTINGENCIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BUSINESSREORGANIZATION" xlink:type="simple" xlink:href="ttwo-20201231.xsd#BUSINESSREORGANIZATION"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BUSINESSREORGANIZATION" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BUSINESSREORGANIZATIONDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#BUSINESSREORGANIZATIONDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BUSINESSREORGANIZATIONDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INCOMETAXES" xlink:type="simple" xlink:href="ttwo-20201231.xsd#INCOMETAXES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INCOMETAXES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INCOMETAXESDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#INCOMETAXESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INCOMETAXESDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONS" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSTables" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSScheduleofConsiderationatFairValueDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSScheduleofConsiderationatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSScheduleofConsiderationatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_a2af389e-de8a-468c-806d-fca89e70664f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_05540e23-adfc-4095-ae3b-2482f9a10459" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_a2af389e-de8a-468c-806d-fca89e70664f" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_05540e23-adfc-4095-ae3b-2482f9a10459" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_0fd12007-7766-4fe7-a208-b8ad41a248be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_a2af389e-de8a-468c-806d-fca89e70664f" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_0fd12007-7766-4fe7-a208-b8ad41a248be" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSScheduleofAssetsandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSScheduleofAssetsandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSScheduleofAssetsandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_0fee7057-9336-4f5b-9c88-31cdf992483c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_0fee7057-9336-4f5b-9c88-31cdf992483c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_21e57db8-817a-47e9-a35d-2b272780d83d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_21e57db8-817a-47e9-a35d-2b272780d83d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_3a2530a3-fefd-4a75-9f05-bf408fce09f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:to="loc_us-gaap_Goodwill_3a2530a3-fefd-4a75-9f05-bf408fce09f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredOther_696a2eaa-7bc8-4824-8225-4459afbd8640" xlink:href="ttwo-20201231.xsd#ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:to="loc_ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredOther_696a2eaa-7bc8-4824-8225-4459afbd8640" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3c261d9b-294d-482b-93a0-1749b5aa9db6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_545e64ba-0dd7-4998-b81a-30306839dffa" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_3c261d9b-294d-482b-93a0-1749b5aa9db6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSScheduleofRevenueandEarningsIncludedinStatementofOperationsDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSScheduleofRevenueandEarningsIncludedinStatementofOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSScheduleofRevenueandEarningsIncludedinStatementofOperationsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACQUISITIONSScheduleofProFormaInformationDetails" xlink:type="simple" xlink:href="ttwo-20201231.xsd#ACQUISITIONSScheduleofProFormaInformationDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACQUISITIONSScheduleofProFormaInformationDetails" xlink:type="extended"/>
</link:linkbase>
