<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:832eccb0-477c-4e1d-9043-147b839d8021,g:52a518e9-a7d9-4cc6-86f8-9f44b7dd9814-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.take2games.com/role/COVER" xlink:type="simple" xlink:href="ttwo-20200630.xsd#COVER"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/COVER" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_7f6fcb68-4529-4d42-8eda-42a53af6fab9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_PreferredStockValue_7f6fcb68-4529-4d42-8eda-42a53af6fab9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_628474f9-bc8e-47b6-9456-4ba90e3c6246" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_CommonStockValue_628474f9-bc8e-47b6-9456-4ba90e3c6246" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_5507f943-ac5d-4a60-b5ba-a2dc4dd0bd3e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_5507f943-ac5d-4a60-b5ba-a2dc4dd0bd3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_239403cd-d5ee-4eae-8357-69ee9df1d2ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_239403cd-d5ee-4eae-8357-69ee9df1d2ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_fdda0979-2d4a-4256-bd5c-7d253afc0967" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_TreasuryStockValue_fdda0979-2d4a-4256-bd5c-7d253afc0967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_a4ca2807-3c30-4ade-bc21-08e5ff8c618b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_9c20dcea-9daf-4e39-8807-62d97cb5dcd3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_a4ca2807-3c30-4ade-bc21-08e5ff8c618b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c83f8ba7-2cee-44ca-a644-161774f0af55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c83f8ba7-2cee-44ca-a644-161774f0af55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_c3202622-ec61-4bab-92da-29ddfa17c072" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_ShortTermInvestments_c3202622-ec61-4bab-92da-29ddfa17c072" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_bdad2bd3-cb36-4ef9-a602-c0faf4aca3e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_bdad2bd3-cb36-4ef9-a602-c0faf4aca3e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_49f01151-0172-4acb-91b7-991390058ab0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_49f01151-0172-4acb-91b7-991390058ab0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_3a6fb8ba-6a02-4bf5-bc65-c74d3d8e95d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_InventoryNet_3a6fb8ba-6a02-4bf5-bc65-c74d3d8e95d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_79fbed9d-bc1b-40e0-915d-4619c5d4d964" xlink:href="ttwo-20200630.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesCurrent_79fbed9d-bc1b-40e0-915d-4619c5d4d964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCostsCurrent_9aa6a2e9-b234-4eaf-9490-2941264e8358" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredCostsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_DeferredCostsCurrent_9aa6a2e9-b234-4eaf-9490-2941264e8358" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2e2cc9ce-4eb9-493e-9cf8-eea12e245988" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_cc8eeec4-a55e-4c78-b70d-8f69bfdc8c08" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_2e2cc9ce-4eb9-493e-9cf8-eea12e245988" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_b027853f-5a45-413d-ad40-2d4a84a571df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_AssetsCurrent_b027853f-5a45-413d-ad40-2d4a84a571df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_8b8bb1b8-466b-4940-b77d-3bd2633d412f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_8b8bb1b8-466b-4940-b77d-3bd2633d412f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_a0c85036-6398-4a54-8937-9c2b1171fc32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_Goodwill_a0c85036-6398-4a54-8937-9c2b1171fc32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_c4578bd2-ecf5-44d7-a2b9-3392c1a9f0da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_c4578bd2-ecf5-44d7-a2b9-3392c1a9f0da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_91958eee-a596-4065-8e89-660f201afa8d" xlink:href="ttwo-20200630.xsd#ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent_91958eee-a596-4065-8e89-660f201afa8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_34bc4ce6-94cb-4b46-af11-172381b035c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_34bc4ce6-94cb-4b46-af11-172381b035c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_341db16e-73a8-4f09-9715-466c5d26b1c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_341db16e-73a8-4f09-9715-466c5d26b1c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_4ee1eb69-c079-4efb-8443-13a101af67f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_4ee1eb69-c079-4efb-8443-13a101af67f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_feba0e84-c7df-470f-bdba-bf1e9d4c3710" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_828d4c5c-8329-4b4a-8ef6-055858b7ed68" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_feba0e84-c7df-470f-bdba-bf1e9d4c3710" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_55380965-e833-4c0b-8260-40e0b34db4a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_b403c5bd-dc76-4927-94b0-97176fd90373" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_55380965-e833-4c0b-8260-40e0b34db4a6" xlink:to="loc_us-gaap_AccountsPayableCurrent_b403c5bd-dc76-4927-94b0-97176fd90373" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_dba5e327-3d10-4e29-b0e5-7ed0dd7efe99" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_55380965-e833-4c0b-8260-40e0b34db4a6" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_dba5e327-3d10-4e29-b0e5-7ed0dd7efe99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_9829f57b-ac75-4f95-a937-577efe48d140" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_55380965-e833-4c0b-8260-40e0b34db4a6" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_9829f57b-ac75-4f95-a937-577efe48d140" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_995c2df9-ac5e-433e-b4c5-c444809f245a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_55380965-e833-4c0b-8260-40e0b34db4a6" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_995c2df9-ac5e-433e-b4c5-c444809f245a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_d64f0a99-9005-4add-8aa3-766c74ee3c39" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:to="loc_us-gaap_LiabilitiesCurrent_d64f0a99-9005-4add-8aa3-766c74ee3c39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_20156adf-c3cd-4e22-94dd-60e71c4848a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_20156adf-c3cd-4e22-94dd-60e71c4848a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_8334dd86-e46d-4396-8f41-8e3c52200d76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_8334dd86-e46d-4396-8f41-8e3c52200d76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedRoyaltiesNoncurrent_7bf27323-19b3-4a54-ba29-5459c39ba677" xlink:href="ttwo-20200630.xsd#ttwo_AccruedRoyaltiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:to="loc_ttwo_AccruedRoyaltiesNoncurrent_7bf27323-19b3-4a54-ba29-5459c39ba677" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3ecf8b99-59b0-4107-9820-bfd65e51ee85" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_856be819-9c6b-4618-bf8c-347a2cfdeb3a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3ecf8b99-59b0-4107-9820-bfd65e51ee85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_4a9f9341-b5c4-4522-8ce1-2c086ce56498" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_b4025e28-a632-4da4-97c1-4178cb86b4fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4a9f9341-b5c4-4522-8ce1-2c086ce56498" xlink:to="loc_us-gaap_Liabilities_b4025e28-a632-4da4-97c1-4178cb86b4fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_053e9307-a599-47ce-96c5-34ad8a25d390" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4a9f9341-b5c4-4522-8ce1-2c086ce56498" xlink:to="loc_us-gaap_StockholdersEquity_053e9307-a599-47ce-96c5-34ad8a25d390" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_083990cc-37a3-4cca-9814-15e034c5e0d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4a9f9341-b5c4-4522-8ce1-2c086ce56498" xlink:to="loc_us-gaap_CommitmentsAndContingencies_083990cc-37a3-4cca-9814-15e034c5e0d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5ae0c0ad-5e29-4494-84bf-9f7b9a4b36fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_0fbe06ce-6707-4166-914d-2b6e77622d96" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5ae0c0ad-5e29-4494-84bf-9f7b9a4b36fa" xlink:to="loc_us-gaap_OperatingIncomeLoss_0fbe06ce-6707-4166-914d-2b6e77622d96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_bbeb435c-168b-4f17-8d82-55e2b377f8fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5ae0c0ad-5e29-4494-84bf-9f7b9a4b36fa" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_bbeb435c-168b-4f17-8d82-55e2b377f8fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_2f2d3f40-6870-45d2-81f5-56d44547821f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:to="loc_us-gaap_SellingAndMarketingExpense_2f2d3f40-6870-45d2-81f5-56d44547821f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_bf8dc5a4-c40d-46c5-a6bd-85e1dd6977cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_bf8dc5a4-c40d-46c5-a6bd-85e1dd6977cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_ff9a5ef7-be15-4ff5-a94a-fdde74b82cc8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseSoftwareExcludingAcquiredInProcessCost_ff9a5ef7-be15-4ff5-a94a-fdde74b82cc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_e7916115-1659-4c0b-b264-c377a10b4e19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:to="loc_us-gaap_RestructuringCharges_e7916115-1659-4c0b-b264-c377a10b4e19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_29007047-4fd3-44de-9290-e772021800cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_98d38277-08d9-4a37-8dda-f72fa0f415db" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_29007047-4fd3-44de-9290-e772021800cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d941d4f2-62c2-4354-ad2e-baf6258a39a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_506a7f5d-3829-40a8-ae5a-2b8870832ae7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d941d4f2-62c2-4354-ad2e-baf6258a39a9" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_506a7f5d-3829-40a8-ae5a-2b8870832ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_8867b706-907e-4b15-8270-03234e48b5a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d941d4f2-62c2-4354-ad2e-baf6258a39a9" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_8867b706-907e-4b15-8270-03234e48b5a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ca5584b2-b7c9-425a-83a2-f43813dfa7bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_3bb2ae29-5f72-43e1-a210-7434d86dc537" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ca5584b2-b7c9-425a-83a2-f43813dfa7bf" xlink:to="loc_us-gaap_GrossProfit_3bb2ae29-5f72-43e1-a210-7434d86dc537" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_5d7440ef-54a8-44c7-8b70-24a4b55d78ea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ca5584b2-b7c9-425a-83a2-f43813dfa7bf" xlink:to="loc_us-gaap_OperatingExpenses_5d7440ef-54a8-44c7-8b70-24a4b55d78ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_2da7481e-d8a4-43d7-ad10-4522bb5d1798" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b1bba4c7-8cf2-4648-b936-9aacdfe7ad62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_2da7481e-d8a4-43d7-ad10-4522bb5d1798" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b1bba4c7-8cf2-4648-b936-9aacdfe7ad62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_db7cd929-1c26-49e5-a72e-c84e3e76b4c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_2da7481e-d8a4-43d7-ad10-4522bb5d1798" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_db7cd929-1c26-49e5-a72e-c84e3e76b4c9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_eae69add-2151-43d3-b106-8571987c75c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ca59dd50-4254-4517-9a92-d476defdae36" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_eae69add-2151-43d3-b106-8571987c75c6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_ca59dd50-4254-4517-9a92-d476defdae36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_767be6a0-ff67-401f-877a-6149793b368e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_eae69add-2151-43d3-b106-8571987c75c6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_767be6a0-ff67-401f-877a-6149793b368e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent_c594e255-1a1c-4933-af67-84e974e6b398" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_eae69add-2151-43d3-b106-8571987c75c6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationTaxParent_c594e255-1a1c-4933-af67-84e974e6b398" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_637b5edc-8393-4d4d-bc7a-040c892414a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_43acf27f-edbf-4931-984e-52b37c2cebef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_637b5edc-8393-4d4d-bc7a-040c892414a8" xlink:to="loc_us-gaap_NetIncomeLoss_43acf27f-edbf-4931-984e-52b37c2cebef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_204d4dd8-3c3f-4894-a84e-91c86a907f50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_637b5edc-8393-4d4d-bc7a-040c892414a8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_204d4dd8-3c3f-4894-a84e-91c86a907f50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4d9a76c4-35ef-4203-8ada-9c48b2c73937" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_66fba722-552c-4b9c-a32d-62f6565d342d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4d9a76c4-35ef-4203-8ada-9c48b2c73937" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_66fba722-552c-4b9c-a32d-62f6565d342d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_a6ae8409-4a2d-40f0-9286-f4fd9dc98ca1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4d9a76c4-35ef-4203-8ada-9c48b2c73937" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_a6ae8409-4a2d-40f0-9286-f4fd9dc98ca1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_e8f0bbd3-b219-490f-8b34-0d0e20ba8b90" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4d9a76c4-35ef-4203-8ada-9c48b2c73937" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_e8f0bbd3-b219-490f-8b34-0d0e20ba8b90" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_879b16bc-d8f7-4660-b6c6-989d6fbb81cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_b9d36cde-e314-4238-a30d-afc0c6f4f407" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_879b16bc-d8f7-4660-b6c6-989d6fbb81cf" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_b9d36cde-e314-4238-a30d-afc0c6f4f407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_043f9d5c-7d72-4164-98ba-ca15ba4af9a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_879b16bc-d8f7-4660-b6c6-989d6fbb81cf" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_043f9d5c-7d72-4164-98ba-ca15ba4af9a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_eaf8251e-3580-4d7a-af3f-c1be7f7c2c0f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_NetIncomeLoss_eaf8251e-3580-4d7a-af3f-c1be7f7c2c0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_2ee2e094-751e-493a-b41b-7c1bfc9a3326" xlink:href="ttwo-20200630.xsd#ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_ttwo_AmortizationAndImpairmentOfSoftwareDevelopmentCostsAndLicenses_2ee2e094-751e-493a-b41b-7c1bfc9a3326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_7e495b84-383c-45cb-ab93-dd877c2a0201" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_Depreciation_7e495b84-383c-45cb-ab93-dd877c2a0201" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AmortizationAndImpairmentOfIntellectualProperty_81e354f1-7ca6-481a-9aa2-6029a240b165" xlink:href="ttwo-20200630.xsd#ttwo_AmortizationAndImpairmentOfIntellectualProperty"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_ttwo_AmortizationAndImpairmentOfIntellectualProperty_81e354f1-7ca6-481a-9aa2-6029a240b165" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_d3f2845c-6344-42bc-a90e-6085e00e3f04" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_ShareBasedCompensation_d3f2845c-6344-42bc-a90e-6085e00e3f04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_c4297297-0eb9-4eac-9b77-86e43dcadf7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_c4297297-0eb9-4eac-9b77-86e43dcadf7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_26d6958d-49a7-44ac-9445-3b3b95815d1b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_26d6958d-49a7-44ac-9445-3b3b95815d1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_9b85f433-ed91-4b13-8346-2e50ed4deb1c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_9b85f433-ed91-4b13-8346-2e50ed4deb1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_127d09fc-72b6-4f2d-b5c5-0e98b1c7135e" xlink:href="ttwo-20200630.xsd#ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_ttwo_IncreaseDecreaseInSoftwareDevelopmentCostsAndLicenses_127d09fc-72b6-4f2d-b5c5-0e98b1c7135e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5659a4c9-d24d-493e-9f5b-a0be4bc8b388" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5659a4c9-d24d-493e-9f5b-a0be4bc8b388" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_65985990-5623-463e-9e18-d2cf95480b3b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_65985990-5623-463e-9e18-d2cf95480b3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredCharges_606e0d82-7559-4d77-bdf6-c382e7c7d7a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredCharges"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredCharges_606e0d82-7559-4d77-bdf6-c382e7c7d7a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_cd6833c1-251a-4e83-addd-7199e4d2420b" xlink:href="ttwo-20200630.xsd#ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27652ec9-7f2c-4890-b63c-4fe52b8ef67c" xlink:to="loc_ttwo_AccountsPayableAccruedExpensesIncomeTaxesPayableAndOtherLiabilities_cd6833c1-251a-4e83-addd-7199e4d2420b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_937151dd-cccd-40a3-abeb-7edfc19def52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a7d1dd74-bf42-4f41-94fc-eb0cb49efafd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_937151dd-cccd-40a3-abeb-7edfc19def52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a7d1dd74-bf42-4f41-94fc-eb0cb49efafd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a1414f35-6696-4760-a869-f1d9d7689450" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_937151dd-cccd-40a3-abeb-7edfc19def52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a1414f35-6696-4760-a869-f1d9d7689450" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_581d0f69-c2c0-4a92-9b2f-c800808659dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_937151dd-cccd-40a3-abeb-7edfc19def52" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_581d0f69-c2c0-4a92-9b2f-c800808659dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7491f52-d164-4de5-8d4a-87b892851c87" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_937151dd-cccd-40a3-abeb-7edfc19def52" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7491f52-d164-4de5-8d4a-87b892851c87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_8b3a45a4-ef67-49f8-9e86-daca545c2556" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_8b3a45a4-ef67-49f8-9e86-daca545c2556" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_033ee3cc-0497-42b7-bd90-d4e4330ffe21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_033ee3cc-0497-42b7-bd90-d4e4330ffe21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_ab91c285-c327-4ff9-9edd-238905114085" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_ab91c285-c327-4ff9-9edd-238905114085" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_5e6246f9-2425-40cb-b310-76ee73b45b65" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_5e6246f9-2425-40cb-b310-76ee73b45b65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_a370faf7-ad9a-43c5-b73c-591e801a21d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireLongtermInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_a370faf7-ad9a-43c5-b73c-591e801a21d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_9ac1e8ba-b161-4e23-9b6d-24156eb0e827" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eab8b9cd-7901-4d8e-8323-32a59f89f06c" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_9ac1e8ba-b161-4e23-9b6d-24156eb0e827" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="ttwo-20200630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="simple" xlink:href="ttwo-20200630.xsd#BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSDisaggregatedRevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSGeographicalDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="simple" xlink:href="ttwo-20200630.xsd#REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/REVENUEFROMCONTRACTSWITHCUSTOMERSNarrativeDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENT" xlink:type="simple" xlink:href="ttwo-20200630.xsd#MANAGEMENTAGREEMENT"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENT" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#MANAGEMENTAGREEMENTTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/MANAGEMENTAGREEMENTDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#MANAGEMENTAGREEMENTDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/MANAGEMENTAGREEMENTDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#FAIRVALUEMEASUREMENTS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#FAIRVALUEMEASUREMENTSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSASSETSMEASUREDATFAIRVALUEDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#FAIRVALUEMEASUREMENTSASSETSMEASUREDATFAIRVALUEDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/FAIRVALUEMEASUREMENTSASSETSMEASUREDATFAIRVALUEDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueNetAssetLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashAtFairValue_bf2c1be8-0e51-4b84-8a57-1f38927a3bf7" xlink:href="ttwo-20200630.xsd#ttwo_RestrictedCashAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_ttwo_RestrictedCashAtFairValue_bf2c1be8-0e51-4b84-8a57-1f38927a3bf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f4ef689e-c491-474c-b55a-e4ca920c0425" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f4ef689e-c491-474c-b55a-e4ca920c0425" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_eff1ad49-bc9b-428a-b875-005fde418aaa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_us-gaap_ShortTermInvestments_eff1ad49-bc9b-428a-b875-005fde418aaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_d2cf9e00-3696-4cbd-84e9-2c91916acbf6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_us-gaap_DerivativeAssets_d2cf9e00-3696-4cbd-84e9-2c91916acbf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_2ea9f780-4725-4615-9935-115b1956bde7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_2ea9f780-4725-4615-9935-115b1956bde7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_b925fb6c-b3ce-4142-a157-6a423a0d7073" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_us-gaap_DerivativeLiabilities_b925fb6c-b3ce-4142-a157-6a423a0d7073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_0c39628d-efb7-4023-8d17-2411c7f44399" xlink:href="ttwo-20200630.xsd#ttwo_RestrictedCashNoncurrentFairValueDisclosure"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FairValueNetAssetLiability_ebc5d2d8-34c8-4e14-b534-38d8bc564469" xlink:to="loc_ttwo_RestrictedCashNoncurrentFairValueDisclosure_0c39628d-efb7-4023-8d17-2411c7f44399" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SHORTTERMINVESTMENTS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SHORTTERMINVESTMENTSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SHORTTERMINVESTMENTSDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_00975bc4-2247-4de5-83c2-5493e60204dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_eb6a9e72-f9ee-4dfa-98c7-a86a9e54007d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_00975bc4-2247-4de5-83c2-5493e60204dd" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_eb6a9e72-f9ee-4dfa-98c7-a86a9e54007d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_e7966422-c039-4e59-bfd5-d41708be1e5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_00975bc4-2247-4de5-83c2-5493e60204dd" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_e7966422-c039-4e59-bfd5-d41708be1e5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_3100a8c3-6edd-4d22-a85c-74858f1b6f46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_00975bc4-2247-4de5-83c2-5493e60204dd" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_3100a8c3-6edd-4d22-a85c-74858f1b6f46" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SHORTTERMINVESTMENTSContractedMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SHORTTERMINVESTMENTSContractedMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c7978d13-4870-4d7a-bc4a-d16ecd3c2087" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fc832799-7f36-471d-9c48-ffa8b97ebf16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c7978d13-4870-4d7a-bc4a-d16ecd3c2087" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fc832799-7f36-471d-9c48-ffa8b97ebf16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_f8e3c666-7681-402f-a4f7-caa43b424c0c" xlink:href="ttwo-20200630.xsd#ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c7978d13-4870-4d7a-bc4a-d16ecd3c2087" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_f8e3c666-7681-402f-a4f7-caa43b424c0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_9a781119-b29f-4750-bfc7-0b4875ea7de4" xlink:href="ttwo-20200630.xsd#ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c7978d13-4870-4d7a-bc4a-d16ecd3c2087" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_9a781119-b29f-4750-bfc7-0b4875ea7de4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_67c4d396-076a-43b8-a8d8-0c6db56a7e9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_2337c43f-83de-4e70-b162-a3393e3451ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_67c4d396-076a-43b8-a8d8-0c6db56a7e9a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_2337c43f-83de-4e70-b162-a3393e3451ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_4188bb8a-7fae-4960-bb3e-410074983e35" xlink:href="ttwo-20200630.xsd#ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_67c4d396-076a-43b8-a8d8-0c6db56a7e9a" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_4188bb8a-7fae-4960-bb3e-410074983e35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_1730a6fd-c940-47a6-90a4-8a4312e756a1" xlink:href="ttwo-20200630.xsd#ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_67c4d396-076a-43b8-a8d8-0c6db56a7e9a" xlink:to="loc_ttwo_DebtSecuritiesAvailableForSaleAmortizedCostMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_1730a6fd-c940-47a6-90a4-8a4312e756a1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DERIVATIVEINSTRUMENTSANDHEDGINGACTIVITIESDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORY" xlink:type="simple" xlink:href="ttwo-20200630.xsd#INVENTORY"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORYTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#INVENTORYTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORYTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INVENTORYDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#INVENTORYDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INVENTORYDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_ae354bdb-6e53-44fd-b6b2-020505f4704c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_107cc3ff-c544-4f77-92de-db11b5316205" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ae354bdb-6e53-44fd-b6b2-020505f4704c" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_107cc3ff-c544-4f77-92de-db11b5316205" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_61934905-365f-4383-ad2f-ece92594c88f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ae354bdb-6e53-44fd-b6b2-020505f4704c" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSuppliesNetOfReserves_61934905-365f-4383-ad2f-ece92594c88f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/SOFTWAREDEVELOPMENTCOSTSANDLICENSESDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_093b5517-4ab0-446d-9c48-c0c83597c92c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_093b5517-4ab0-446d-9c48-c0c83597c92c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_3aae7fa1-7354-49f3-ad5a-2d93e8493cee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_3aae7fa1-7354-49f3-ad5a-2d93e8493cee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_AccruedLicensesCurrent_5e92810a-e5e1-42bb-aadc-5e17ee018943" xlink:href="ttwo-20200630.xsd#ttwo_AccruedLicensesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_ttwo_AccruedLicensesCurrent_5e92810a-e5e1-42bb-aadc-5e17ee018943" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_5dc1666f-955d-4bab-9e0f-a0a4dfe035df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_5dc1666f-955d-4bab-9e0f-a0a4dfe035df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_08d8d966-f3ee-41b1-bee8-6884cd7a736e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_08d8d966-f3ee-41b1-bee8-6884cd7a736e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRefundLiabilityCurrent_266a42ba-a310-4d64-8c03-0cb5a758ce34" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_de85f76f-507b-4dc3-86e4-53ff16adead0" xlink:to="loc_us-gaap_CustomerRefundLiabilityCurrent_266a42ba-a310-4d64-8c03-0cb5a758ce34" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBT" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DEBT"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBT" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DEBTTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/DEBTCREDITAGREEMENTDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#DEBTCREDITAGREEMENTDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/DEBTCREDITAGREEMENTDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#EARNINGSPERSHAREEPS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#EARNINGSPERSHAREEPSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#EARNINGSPERSHAREEPSDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_678302c4-46c6-46ec-938f-100b87deaf1c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet_efe460d2-8ced-4d18-ae22-b3560da66e80" xlink:href="ttwo-20200630.xsd#ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_678302c4-46c6-46ec-938f-100b87deaf1c" xlink:to="loc_ttwo_WeightedAverageNumberOfSharesOutstandingBasicNet_efe460d2-8ced-4d18-ae22-b3560da66e80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1534a6ac-d957-4e66-a10a-cf719e9a175b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_678302c4-46c6-46ec-938f-100b87deaf1c" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1534a6ac-d957-4e66-a10a-cf719e9a175b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.take2games.com/role/EARNINGSPERSHAREEPSNarrativeDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#EARNINGSPERSHAREEPSNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/EARNINGSPERSHAREEPSNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSTables" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSTables"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/ACCUMULATEDOTHERCOMPREHENSIVELOSSDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#COMMITMENTSANDCONTINGENCIES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/COMMITMENTSANDCONTINGENCIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BUSINESSREORGANIZATION" xlink:type="simple" xlink:href="ttwo-20200630.xsd#BUSINESSREORGANIZATION"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BUSINESSREORGANIZATION" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/BUSINESSREORGANIZATIONDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#BUSINESSREORGANIZATIONDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/BUSINESSREORGANIZATIONDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INCOMETAXES" xlink:type="simple" xlink:href="ttwo-20200630.xsd#INCOMETAXES"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INCOMETAXES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.take2games.com/role/INCOMETAXESDetails" xlink:type="simple" xlink:href="ttwo-20200630.xsd#INCOMETAXESDetails"/>
  <link:calculationLink xlink:role="http://www.take2games.com/role/INCOMETAXESDetails" xlink:type="extended"/>
</link:linkbase>
